IMMUNOHISTOCHEMICAL STUDIES ON THE LOCALIZATION OF ANTIGEN-BEARING PHAGOCYTES AND LYMPHOCYTES IN MOUSE LYMPH NODES AFTER THE GERMINAL CENTER FORMATION

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概要

• 論文の詳細を見る

• The antigen, 2,4-dinitrophenylated and alumprecipitated bovine serum albumin, was inoculated into the foot pads at 2 weeks after the primary inoculation of the antigen. At 2 and 3 days after the second inoculation, many anti-T cell serum negative lymphocytes, possibly B cells, were found in the lumen and the endothelium of the post capillary venules, and they predominantly gathered around the venules. These gathering areas of possibly B cells were encountered frequently in contact with the cortical lymphatic nodules containing the germinal centers. From 4 to 14 days after the second inoculation, a number of antigen-bearing phagocytes appeared in the cortical marginal zones, which were located between the germinal centers and the marginal sinuses. These findings suggest that B cells are largely recruited from the blood to the paracortex, and also the antigen-bearing phagocytes directly present the antigen to the cortical lymphocytes for the acceleration of the antibody production after the formation of the germinal centers.

• 北海道大学の論文
• 1984-04-28

著者

• KITAGAWA Hiroshi

  Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University

• Kudo Norio

  Department Of Physiology Institute Of Basic Medical Sciences University Of Tsukuba

• Kudo Norio

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Kudo Norio

  Biotechnology Research Center The University Of Tokyo

• Hashimoto Yoshiharu

  Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Hokkaido University

• NAKAMURA Kazuichi

  Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Hokkaido University

• Nakamura Kazuichi

  Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Hokkaido University

• Kitamura Hirokazu

  Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Hokkaido University

• Kitagawa Hiroshi

  Laboratory Of Animal Histophysiology Division Of Animal Science Department Of Bioresource Science Gr

• Kitagawa Hiroshi

  Department Of Adaptive Machine Systems Graduate School Of Engineering Osaka University

• Kitagawa Hiroshi

  Department Of Animal Science Graduate School Of Agricultural Science Kobe University

• Kitagawa Hiroshi

  Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Hokkaido University

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