EFFECT OF CYCLOPHOSPHAMIDE ON THE THYMUS AND THE BURSA OF FABRICIUS IN CHICKENS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of cyclophosphamide (Cy) on the thymus and the bursa of Fabricius in chickens, aged one day to 7 weeks, was examined morphologically. Chickens, which were daily injected i.m. with 6 mg Cy 1,2,or 3 times from the hatching day, were compared with saline control chickens. The relative weights of both the thymus and the bursa decreased abruptly just after the injection of Cy. The weight of the thymus had an involutional bottom at the age of 4〜5 days, and thereafter recovered to the normal level at age 3 weeks, while that of the bursa never returned to the control level until age 7 weeks. The histological changes in the thymus appeared to be greater in the cortex than in the medulla. A degeneration of lymphocytes, an increase of macrophages, hypertrophy of the reticular cells, and a disappearance of mitotic cells were observed in the cortex during early involution. Recovery began as soon as the large lymphocytes appeared in the cortex, and the histological structures of the thymuses in the Cy-treated birds recovered completely at age 3 weeks. The effect of Cy in the bursa was similar to that in the thymus, but these changes were seen earlier than they were in the thymus. Restoration of the lymphoid follicles was observed from 5 to 10 days of age mainly in the groups treated with a smaller quantity of Cy. In the chickens treated with 18 mg Cy, however, only a few restorative follicles were found.
- 北海道大学の論文
著者
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HIRAGA TAKEO
Department of Toxicology, Shool of Veterinary Medicine, Rakuno Gakuen University
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杉村 誠
北大
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KUDO Norio
Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Hokkaido University
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SUGIMURA Makoto
Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Hokkaido University
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Hiraga Takeo
Department Of Toxicology
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Hiraga Takeo
Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Hokkaido University
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Kudo Norio
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Sugimura Makoto
Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Hokkaido University
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Sugimura Makoto
Institut Fur Veterinar-anatomie Tierarztliche Fakultat Hokkaido-universitat:(jetzige Adresse) Instit
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Sugimura Makoto
Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Hokkaido University:(present Address
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Sugimura Makoto
Department Of Veterinary Anatomy
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Sugimura Makoto
Department Of Veterinary Anatomy Faculty Of Veterinay Medicine Hokkaido University
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