Nicotinic Receptor-mediated Ca2+ Mobilization and Catecholamine Secretion in Chick Adrenal Chromaffin Cells.
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概要
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We reinvestigated the involvement of the nicotinic-acetylcholine receptor in catecholamine secretion from chick adrenal chromaffin cells. Nicotine (10-8-10-4M), as well as methacholine, caused a dose-dependent increase in the cytosolic concentration of Ca2+ and catecholamine secretion from freshly isolated adrenal chromaffin cells. The effects of acetylcholine (10-4M) were effectively inhibited by both hexamethonium (10-4M) and atropine (10-5M), and almost completely blocked by both antagonists. The results suggest the existence of functional nicotinic receptors, which mediate Ca2+ mobilization and catecholamine secretion, in chromaffin cells of chick adrenal glands.
- 日本学士院の論文
著者
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Teraoka Hiroki
Department Of Internal Medicine Uwajima City Hospital
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Hiraga Takeo
Department Of Toxicology
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Maruyama Yutaka
Department Of Toxicology School Of Veterinary Medicine Rakuno-gakuen University
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Ohga Akira
Department Of Pharmacology Faculty Of Veterinary Medicine Hokkaido University
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HIRAGA Takeo
Department of Toxicology, Faculty of Veterinary Medicine, Rakuno-Gakuen University
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MATSUZAWA Rumiko
Department of Toxicology, Faculty of Veterinary Medicine, Rakuno-Gakuen University
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Teraoka Hiroki
Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine
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TERAOKA Hiroki
Department of Toxicology, Faculty of Veterinary Medicine, Rakuno-Gakuen University
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