THE INHIBITORY ACTION OF LEAD ON MECHANICAL RESPONSES OF THE PROVENTRICULAR SMOOTH MUSCLE IN THE CHICK
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of the present experiments was to examine the mechanism of the proventricular dilatation caused by lead in the isolated vagus nerveproventricular smooth muscle preparation of the chick. Lead caused dose- and time-dependent inhibition of contractions induced by vagal stimulation, transmural stimulation and externally applied acetylcholine (ACh). Vagally evoked contraction was much more sensitive to the inhibitory action of lead than the contractile response to ACh. The lower the frequency of transmural stimulation, or the lower the concentration of ACh was applied, the greater the inhibitory action of lead on the evoked smooth muscle contraction. The results suggest that proventricular impaction occurring in lead poisoning results from the pre- and postsynaptic inhibition of the vagus nerve-smooth muscle transmission.
- 北海道大学の論文
- 1995-01-31
著者
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OHGA Akira
Department of Toxicology
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NAKAZATO Yoshikazu
Department of Pharmacology, Faculty of Veterinary Medicine, Hokkaido University
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Nakazato Yoshikazu
Laboratory Of Pharmacology Graduate School Of Veterinary Medicine Hokkaido University
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Nakazato Yoshikazu
Department Of Clinical Studies Samora Machel School Of Veterinary Medicine University Of Zambia
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Ohga Akira
Department Of Pharmacology Faculty Of Veterinary Medicine Hokkaido University
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Ohga Akira
Department Of Veterinary Medicine Faculty Of Dairy Science Rakuno Gakuen University
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Ito Shigeo
Laboratory Of Pharmacology Graduate School Of Veterinary Medicine Hokkaido University
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Ohta Toshio
Laboratory Of Pharmacology Graduate School Of Veterinary Medicine Hokkaido University
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Ohta Toshio
Department Of Pharmacology Faculty Of Veterinary Medicine Hokkaido University
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KUBOTA Kazufumi
Department of Pharmacology, Faculty of Veterinary Medicine, Hokkaido University
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ITO Shigeo
Department of Pharmacology, Faculty of Veterinary Medicine, Hokkaido University
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Kubota Kazufumi
Department Of Pharmacology Faculty Of Veterinary Medicine Hokkaido University
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Ito Shigeo
Department Of Electrical And Electronic Engineering Toyo University
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Ito Shigeo
Department of Electrical and Communication Engineering, Graduate School of Engineering, Tohoku University, Aoba 05, Aramaki, Aoba-ku, Sendai 980-8579, Japan
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