Immunohistochemical Study on the Secretory Host Defense System of Bactericidal Peptides in Rat Digestive Organs
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概要
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To clarify the fundamental regulation mechanism against indigenous bacterial proliferation in the alimentary tract, we immunohistochemically examined the localization of 4 bactericidal peptides (BP) in the rat digestive exocrine glands. In the upper alimentary tract, lysozyme was detected in the gustatory, extraorbital lacrimal and parotid glands. Secretory phospholipase A2 (sPLA2) was detected in the extraorbital lacrimal glands. β-defensin1 was detected in the gustatory and extraorbital lacrimal glands. β-defensin2 was detected in the Harderian glands. In the stomach, β-defensins were detected in the gastric superficial epithelial cells. In the small and large intestines, only lysozyme and sPLA2 were detected in the Paneth cells. In the cecum, all 4 BP were detected in the middle to apical portions of the crypts, and only sPLA2 was detected in the basal portion. No BP were localized in other exocrine glands associated with the alimentary tract. In addition, all 4 BP were also detected in the columnar epithelial cells of the apical portions of intestinal villi. In the intestinal superficial epithelial cells, lysozyme and β-defensins were detected in the ascending colon, whereas only β-defensin1 was detected in the descending colon and rectum. These results suggest that BP are mainly secreted from exocrine tissues in the initial portion of the digestive tract and play a role in host defense against indigenous bacteria throughout the digestive tract. Part of the BP in the chyme might be absorbed by the epithelium at the most inner sites of mucosae in the small and large intestines.
著者
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MIYATA Hidenori
Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology
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Yokoo Yuh
Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
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UDAYANGA Kankanam
Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
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KAWANO Junichi
Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
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Yokoyama Toshifumi
Department Of Anatomy And Neurobiology Faculty Of Medicine Kagawa University
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Kitagawa Hiroshi
Department Of Adaptive Machine Systems Graduate School Of Engineering Osaka University
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Hoshi Nobuhiko
Department Of Animal Science Graduate School Of Agricultural Science Kobe University
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QI Wang-Mei
Department of Based Veterinary Medicine, College of Veterinary Medicine, Inner Mongolia Agricultural University
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TAKAHARA Ei-ichirou
Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
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UDAYANGA Kankanam
Department of Bioresource Science, Graduate School of Agricultural Science, Graduate School of Science and Technology, Kobe University
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