Tumor Suppressor Candidate TUSC3 Expression during Rat Testis Maturation
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概要
- 論文の詳細を見る
Analysis of microarray data obtained by comparing gene expression between 2-week-old infant and 7-week-old mature SD rat testes revealed novel targets involved in tumor suppression. Reverse-transcription polymerase chain reaction and Northern blotting indicated that Tusc3 gene expression was upregulated in the normal maturing testis and prostate and other organs such as the cerebrum and ovary. Tumor suppressor candidate 3 protein expression was detected in these same organs at a size of about 40 kDa, in accord with the predicted molecular size. In situ hybridization and immunohistochemistry showed that mRNA and protein localization were prevalent in the testis spermatocytes and interstitial cells such as the Leydig cells, as well as prostate epithelial cells. These data suggest that TUSC3 is deeply involved in spermatogenesis in the testis, inducing sperm differentiation and maturation, and plays a role in normal prostate development and tumor suppression.
- 公益社団法人 日本農芸化学会の論文
著者
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Hosaka Yoshinao
Laboratory Of Anatomy Department Of Biomedical Sciences School Of Veterinary Medicine Hokkaido Unive
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Yamano Yoshiaki
Laboratory of Veterinary Biochemistry, Faculty of Agriculture, Tottori University
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Asano Atsushi
Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine
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Yamano Yoshiaki
Laboratory Of Biochemistry Department Of Agricultural Chemistry Kyoto University
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KHALID Ahmed
Laboratory of Veterinary Biochemistry, Faculty of Agriculture, Tottori University
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Khalid Ahmed
Laboratory Of Veterinary Biochemistry Faculty Of Agriculture Tottori University
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Takeuchi Takashi
Department Of Chemical Engineering Science Yokohama National University
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