Active Expression of Matrix Metalloproteinase-13 mRNA in the Granulation Tissue of Equine Superficial Digital Flexor Tendinitis
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概要
- 論文の詳細を見る
The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon. In situ hybridization also revealed that fibroblastic cells proliferated in the granulation tissue generated in the tendinitis actively expressed MMP-13 mRNA. On the other hand, in normal tendon, a few fibroblastic cells and vascular components lied in the endotenon barely expressed its mRNA, but other cellular components in the tendon bundle were not positively hybridized. As mentioned above, MMP-13 but not other collagenases or gelatinases, may play an important role in tendon injuries in the racehorses.
- 公益社団法人 日本獣医学会の論文
著者
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Hosaka Yoshinao
Laboratory Of Anatomy Department Of Biomedical Sciences School Of Veterinary Medicine Hokkaido Unive
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ARAI Katsuhiko
Department of Surgery, Yokohama City Hospital
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TAKEHANA Kazushige
Laboratory of Microanatomy, School of Veterinary Medicine, Rakuno Gakuen University
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KASASHIMA Yoshinori
Laboratory of Clinical Science and Pathobiology, Equine Research Institute, Japan Racing Association, 321–4 Togami-cho, Utsunomiya, Tochigi 320–8056, Japan
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KUWANO Atsutoshi
Laboratory of Clinical Science and Pathobiology, Equine Research Institute, Japan Racing Association, 321–4 Togami-cho, Utsunomiya, Tochigi 320–8056, Japan
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UEDA Hiromi
Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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NOMURA Masayuki
Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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TAKEHANA Kazushige
Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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KUWANO Atsutoshi
Laboratory of Clinical Science and Pathobiology, Equine Research Institute, Japan Racing Association
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KASASHIMA Yoshinori
Laboratory of Clinical Science and Pathobiology, Equine Research Institute, Japan Racing Association
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Arai Katsuhiko
Department of Chemistry, Faculty of Science, Toho University
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