Biological Effects of Chicken Type III Interferon on Expression of Interferon-Stimulated Genes in Chickens: Comparison with Type I and Type II Interferons

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概要

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• Interferons (IFNs) are key mediators that activate host defense mechanisms against viruses. The recently identified mammalian Type III IFN has biological effects similar to type I IFN. However, the biological effects of type III IFN have not yet been characterized in birds. We compared the effects of chicken type III IFN (IFN-λ) with type I (IFN-β) and type II (IFN-γ) IFNs on IFN-stimulated genes (ISGs) using recombinant proteins expressed in Escherichia coli. Recombinant chicken IFN-λ inhibited influenza virus replication and induced the mRNA expression of the ISGs, Mx and OAS, in chicken embryonic fibroblasts (CEFs) in a dose-dependent manner. However, the effective dose of IFN-λ was higher than that of IFN-β and IFN-γ. Furthermore, the effect of IFN-λ on induction of Mx and OAS was lesser than that of IFN-β, but comparable to that of IFN-γ. These results indicate that chicken IFN-λ has the potential to induce ISGs and inhibit viral replication in chicken cells.

著者

• Asano Atsushi

  Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine

• Yamano Yoshiaki

  Laboratory Of Biochemistry Department Of Agricultural Chemistry Kyoto University

• Usui Tatsufumi

  Laboratory Of Infectious Diseases Department Of Disease Control School Of Veterinary Medicine Hokkai

• MATSUDA Akiko

  Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

• YAMANO Yoshiaki

  Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

• USUI Tatsufumi

  Laboratory of Veterinary Hygiene, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

• MASUDA Yasumitsu

  Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

• SUGAI Toru

  Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

• Asano Atsushi

  Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

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