Molecular Changes Associated with Adaptation of Equine Influenza H3N8 Virus in Embryonated Chicken Eggs

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概要

• 論文の詳細を見る

• Embryonated chicken eggs (ECEs) are routinely used to isolate equine influenza virus. Propagation of the virus in ECEs results in selection of variants. In the present study, we determined nucleotide sequences of entire coding regions of parent A/equine/Tottori/1/07 (H3N8) and its derivatives that have different passage histories in ECE. After 12 passages, nucleotide sequence analysis predicted 3 amino acid substitutions in the HA (2 in HA1 and 1 in HA2). The two amino acid substitutions in HA1 were located in the vicinity of the cell receptor-binding site. Other 3 amino acid substitutions were predicted in internal proteins, 1 in the M1; 1 in the NP and 1 in the PA. This is the first report showing mutations in the internal protein genes of equine influenza virus associated with adaptation to ECE.

• 社団法人　日本獣医学会の論文

著者

• ITO TOSHIHIRO

  Departments of Veterinary Public Health, Faculty of Agriculture, Tottori University

• Ito Toshihiro

  Department Of Cardiovascular Medicine Hokkaido University School Of Medicine

• Usui Tatsufumi

  Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medi

• YAMAGUCHI Tsuyoshi

  Laboratory of Veterinary Microbiology, Faculty of Applied Biological Sciences, Gifu University, Gifu

• Usui Tatsufumi

  Laboratory Of Infectious Diseases Department Of Disease Control School Of Veterinary Medicine Hokkai

• SAID Awladwadair

  Laboratory of Veterinary Hygiene, Department of Veterinary Medicine, Faculty of Agriculture, Tottori

• KODANI Michiko

  Tottori Prefecture, Kurayoshi Livesotck Hygiene Service Center

• FUJIMOTO Yoshikazu

  Department of Infectious Diseases, United Graduate School of Veterinary Medicine, Yamaguchi Universi

• ITO Toshihiro

  Department of Infectious Diseases, United Graduate School of Veterinary Medicine, Yamaguchi University

• Said Awlad

  Laboratory of Veterinary Hygiene, Department of Veterinary Medicine, Faculty of Agriculture, Tottori University

• USUI Tatsufumi

  Laboratory of Veterinary Hygiene, Department of Veterinary Medicine, Faculty of Agriculture, Tottori University

• YAMAGUCHI Tsuyoshi

  Laboratory of Veterinary Hygiene, Department of Veterinary Medicine, Faculty of Agriculture, Tottori University

• FUJIMOTO Yoshikazu

  Department of Infectious Diseases, United Graduate School of Veterinary Medicine, Yamaguchi University

• KODANI Michiko

  Tottori Prefecture, Kurayoshi Livestock Hygiene Service Center

• ITO Toshihiro

  Department of Advanced Materials Science, Faculty of Engineering, Kagawa University

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