海生哺乳動物由来インフルエンザAウイルスのレセプター特異性はその宿主の肺のシアル酸糖鎖と相関する

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概要

• 論文の詳細を見る

• The distribution of specific receptors on target organs is a major factor in the host range restriction of influenza A viruses. To assess the correlation between host receptors and the receptor specificity of influenza A viruses from sea mammals, we examined the receptors for influenza A virus in seal and whale lungs. A binding assay using two sialyloligosaccharide (SA_α2,3Gal and SA_α2,6Gal)-specific lectins showed that SAα2,3Gal, but not SAα2,6Gal, was found in both seal and whale lungs. Correspondingly, seal and whale influenza viruses preferentially recognized SAα2,3Gal, but not SAα2,6Gal. These results indicate that sialyloligosaccharides present at the replication site of influenza A viruses correlate with the receptor recognition of the viruses isolated from sea mammals.

• 社団法人日本獣医学会の論文
• 1999-08-25

著者

• ITO TOSHIHIRO

  Departments of Veterinary Public Health, Faculty of Agriculture, Tottori University

• KAWAOKA Yoshihiro

  Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madis

• OTSUKI Koichi

  Department of Veterinary Public Health, Faculty of Agriculture, Tottori University

• Okazaki Katsunori

  Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University

• Okazaki Katsunori

  北海道大学 獣医研究 動物疾病制御

• Kawaoka Y

  St. Jude Children's Res. Hospital Tennessee Usa

• Otsuki K

  Tottori Univ. Tottori Jpn

• Ito Toshihiro

  Department Of Veterinary Public Health Faculty Of Agriculture Tottori University

• Otsuki Koichi

  Department Of Hygiene And Microbiology Faculty Of Veterinary Medicine Hokkaido University

• NOMURA Akiyo

  Department of Veterinary Public Health, Faculty of Agriculture, Tottori University

• Nomura Akiyo

  Department Of Veterinary Public Health Faculty Of Agriculture Tottori University

• Kawaoka Yoshihiro

  Department Of Hygiene And Microbiology Faculty Of Veterinary Medicine Hokkaido University

• Ito Toshihiro

  Department Of Cardiovascular Medicine Hokkaido University School Of Medicine

• ITO Toshihiro

  The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University

• Ito Toshihiro

  The Avian Zoonosis Research Center Faculty Of Agriculture Tottori University

• 河岡 義裕

  Department of Virology and Molecular Biology, St. Jude Children's Research Hospital

• 伊藤 壽啓

  Department of Veterinary Public Health, Faculty of Agriculture, Tottori University

• 野村 明代

  Department of Veterinary Public Health, Faculty of Agriculture, Tottori University

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