Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP
スポンサーリンク
概要
- 論文の詳細を見る
Using biochemical assays, it has been demonstrated that expression of Ebola virus VP40 alone in mammalian cells induced production of particles with a density similar to that of virions. To determine the morphological properties of these particles, cells expressing VP40 and the particles released from the cells were examined by electron microscopy. VP40 induced budding from the plasma membrane of filamentous particles, which differed in length but had uniform diameters of approximately 65 nm. When the Ebola virus glycoprotein (GP) responsible for receptor binding and membrane fusion was expressed in cells, we found pleomorphic particles budding from the plasma membrane. By contrast, when GP was coexpressed with VP40, GP was found on the filamentous particles induced by VP40. These results demonstrated the central role of VP40 in formation of the filamentous structure of Ebola virions and may suggest an interaction between VP40 and GP in morphogenesis.
- American Society for Microbiologyの論文
著者
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Takada Ayato
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Takada Ayato
北海道大学 獣医研究 動物疾病制御
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KIDA Hiroshi
Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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Kawaoka Y
St. Jude Children's Res. Hospital Tennessee Usa
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Kida Hiroshi
東京大 海洋研 大槌臨海研究セ
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高田 礼人
北海道大学人獣共通感染症リサーチセンター
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Sagara Hiroshi
Tokyo Inst. Of Technol.
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Sagara Hiroshi
Research Laboratory For Nuclear Reactor Tokyo Institute Of Technology
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Kida Hiroshi
Hokkaido Univ. Hokkaido Jpn
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Kida Hiroshi
Department Of Disease Control Graduate School Of Veterinary Medicine Hokkkaido University
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Kida Hiroshi
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Kida Hiroshi
Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University
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Noda Takeshi
Institute Of Medical Science University Of Tokyo
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