C-type lectins do not act as functional receptors for filovirus entry into cells
スポンサーリンク
概要
- 論文の詳細を見る
Cellular C-type lectins have been reported to facilitate filovirus infection by binding to glycans on filovirus glycoprotein (GP). However, it is not clearly known whether interaction between C-type lectins and GP mediates all the steps of virus entry (i.e., attachment, internalization, and membrane fusion). In this study, we generated vesicular stomatitis viruses pseudotyped with mutant GPs that have impaired structures of the putative receptor binding regions and thus reduced ability to infect the monkey kidney cells that are routinely used for virus propagation. We found that infectivities of viruses with the mutant GPs dropped in C-type lectin-expressing cells, parallel with those in the monkey kidney cells, whereas binding activities of these GPs to the C-type lectins were not correlated with the infectivities. These results suggest that C-type lectin-mediated entry of filoviruses requires other cellular molecule(s) that may be involved in virion internalization or membrane fusion.
- 2010-12-03
著者
-
Takada Ayato
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
-
Takada Ayato
北海道大学 獣医研究 動物疾病制御
-
高田 礼人
北海道大学人獣共通感染症リサーチセンター
-
Takada A
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
-
Matsuno Keita
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
関連論文
- インフルエンザウイルスの抗原変異予測とワクチン (特集 新型インフルエンザウイルス)
- C-type lectins do not act as functional receptors for filovirus entry into cells
- インフルエンザウイルスの進化における共変異の変化の解析(セッション7)
- Predicting the Antigenic Structure of the Pandemic (H1N1) 2009 Influenza Virus Hemagglutinin
- Disease constraints for utilization of the African buffalo (Syncerus caffer) on game ranches in Zambia
- Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice
- Antigenic and genetic analyses of H5 influenza viruses isolated from ducks in Asia
- Laboratory of Microbiology
- Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions
- Highly Pathogenic H5N1 Influenza Virus Causes Coagulopathy in Chickens
- Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP
- Infectivity-Enhancing Antibodies to Ebola Virus Glycoprotein
- Mucosal vaccination against influenza : Protection of pigs immunized with inactivated virus and ether-split vaccine
- Functional Importance of the Coiled-Coil of the Ebola Virus Glycoprotein
- Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks
- Avirulent Avian Influenza Virus as a Vaccine Strain against a Potential Human Pandemic
- Potentially virulent Newcastle disease viruses are maintained in migratory waterfowl populations
- ACQUISITION OF PATHOGENICITY OF A NEWCASTLE DISEASE VIRUS ISOLATED FROM A JAPANESE QUAIL BY INTRACEREBRAL PASSAGE IN CHICKENS
- Ecology and epidemiology of anthrax in cattle and humans in Zambia
- Characterization of H3N6 avian influenza virus isolated from a wild white pelican in Zambia
- フィロウイルスと細胞膜
- フィロウイルスの細胞への侵入 (特集 ウイルス増殖に関わる宿主細胞分子)
- 鼎談 これからのインフルエンザワクチン
- A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus
- Detection of all known filovirus species by reverse transcription-polymerase chain reaction using a primer set specific for the viral nucleoprotein gene
- Cioning, Tissue Distribution, and Functional Expression of Two Novel Rabbit Cytochrome P450 Isozymes, CYP2D23 and CYP2D24
- インフルエンザウイルスの進化における共変異の変化の解析(セッション7)
- インフルエンザウイルスに対する免疫応答・感染防御機構 (特集 パンデミックインフルエンザ--最新の知見と今後の展望) -- (インフルエンザウイルス研究の進歩)
- エボラ出血熱 (特集 変貌する感染症--人類の備えは十分か?)
- フィロウイルスの病原性と宿主域 (ウイルス研究の現在と展望) -- (ウイルス病原性発現の分子機構)
- エンベロープウイルスの細胞侵入と粒子形成過程
- フィロウイルス感染症
- 北海道大学人獣共通感染症リサーチセンター国際疫学部門
- エボラウイルス表面糖蛋白質の機能解析
- ウイルスの病原性発現における糖タンパク質の役割 (免疫病と感染症)
- Enzyme-Linked Immunosorbent Assay for Detection of Filovirus Species-Specific Antibodies
- Cleavage of the NS2-3 protein in the cells of cattle persistently infected with non-cytopathogenic bovine viral diarrhea virus
- Genetic and Pathobiological Characterization of Bovine Viral Diarrhea Viruses Recently Isolated from Cattle in Japan
- An H5N1 highly pathogenic avian influenza virus that invaded Japan through waterfowl migration
- フィロウイルスの感染機構と宿主因子 (感染現象--その理解の深化から疾患制御への展望) -- (ウイルスと宿主の相互作用)
- いきものの不思議 ウイルスはどうやって生き延びているのか? : インフルエンザウイルスの存続様式と進化