Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
スポンサーリンク
概要
- 論文の詳細を見る
Genetic and biologic observations suggest that pigs may serve as "mixing vessels" for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics. Here we demonstrate a structural basis for this hypothesis. Cell surface receptors for both human and avian influenza viruses were identified in the pig trachea, providing a milieu conducive to viral replication and genetic reassortment. Surprisingly, with continued replication, some avian-like swine viruses acquired the ability to recognize human virus receptors, raising the possibility of their direct transmission to human populations. These findings help to explain the emergence of pandemic influenza viruses and support the need for continued surveillance of swine for viruses carrying avian virus genes.
- American Society for Microbiologyの論文
著者
-
Kawaoka Y
St. Jude Children's Res. Hospital Tennessee Usa
-
Kida Hiroshi
東京大 海洋研 大槌臨海研究セ
-
Ito Toshihiro
Department Of Veterinary Public Health Faculty Of Agriculture Tottori University
-
Kida Hiroshi
Department Of Disease Control Graduate School Of Veterinary Medicine Hokkkaido University
-
ITO Toshihiro
The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University
-
Ito Toshihiro
The Avian Zoonosis Research Center Faculty Of Agriculture Tottori University
-
Kida Hiroshi
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
-
Kida Hiroshi
Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University
関連論文
- Disease constraints for utilization of the African buffalo (Syncerus caffer) on game ranches in Zambia
- Viral and bacterial diseases in livestock in Mongolia
- Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice
- Antigenic and genetic analyses of H5 influenza viruses isolated from ducks in Asia
- Laboratory of Microbiology
- Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions
- Highly Pathogenic H5N1 Influenza Virus Causes Coagulopathy in Chickens
- Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP
- Immunogenicity and Protective Efficacy of Replication-Incompetent Influenza Virus-Like Particles
- Infectivity-Enhancing Antibodies to Ebola Virus Glycoprotein
- Mucosal vaccination against influenza : Protection of pigs immunized with inactivated virus and ether-split vaccine
- Functional Importance of the Coiled-Coil of the Ebola Virus Glycoprotein
- Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks
- Avirulent Avian Influenza Virus as a Vaccine Strain against a Potential Human Pandemic
- 自然界の馬1型および馬2型インフルエンザウイルスの遺伝子進化におけるマトリックス蛋白以外の内部蛋白遺伝子置換
- 鶏および水禽由来ニューカッスル病ウイルスの間のレセプター特異性の相違
- Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
- Potentially virulent Newcastle disease viruses are maintained in migratory waterfowl populations
- ACQUISITION OF PATHOGENICITY OF A NEWCASTLE DISEASE VIRUS ISOLATED FROM A JAPANESE QUAIL BY INTRACEREBRAL PASSAGE IN CHICKENS
- Ecology and epidemiology of anthrax in cattle and humans in Zambia
- A serological survey of minute virus of canines (MVC ; Canine parvovirus type-1) in dogs in the Tokai area of Japan
- A Sero-Survey of Subtype H3 Influenza A Virus Infection in Dogs and Cats in Japan
- Influenza A Virus Can Undergo Multiple Cycles of Replication without M2 Ion Channel Activity
- Antibodies to Human-Related H3 Influenza A Virus in Baikal Seals (Phoca sibirica) and Ringed Seals (Phoca hispida) in Russia
- Influenza virus infection in seal (Phocidae) : seroepidemiological survey of influenza virus in Caspian seals(Phoca caspica)
- Serological Evidence of Transmission of Human Influenza A and B Viruses to Caspian Seals (Phoca caspica)
- Electron-dense deposition patterns and the outcomes of idiopathic membranous nephropathy in Japanese
- DETECTION OF VIRAL GENOME IN NON-NEURAL TISSUES OF CATTLE EXPERIMENTALLY INFECTED WITH BOVINE HERPESVIRUS 1
- Development of an Immunochromatographic Kit for Rapid Diagnosis of H5 Avian Influenza Virus Infection
- A Comparison of the Antibody Responses between Specific Pathogen-Free and Commercial Layers Immunized with an Influenza Vaccine Prepared from Inactivated Non-Pathogenic H5N1 Virus by Single Shot
- 海生哺乳動物由来インフルエンザAウイルスのレセプター特異性はその宿主の肺のシアル酸糖鎖と相関する
- Difference in Receptor Specificity among Influenza A Viruses from Different Species of Animals
- VIRAL DISEASES OF LIVESTOCK IN ZAMBIA
- Genetic Analyses of an H3N8 Influenza Virus Isolate, Causative Strain of the Outbreak of Equine Influenza at the Kanazawa Racecourse in Japan in 2007
- Effective Prevention against Rabies by Intracerebral Immunization in Mice
- BOVINE CLOSTRIDIAL INFECTIONS IN ZAMBIA (1985-1994)
- Methylprednisolone Pulse Therapy in Two Clinical Types of Crescentic Glomerulonephritis
- Efficacy of Intracerebral Immunization against Pseudorabies Virus in Mice
- Possible circulation of H5N1 avian influenza viruses in healthy ducks on farms in northern Vietnam
- Isolation of Pseudomonas aeruginosa from Ushubetsu River water in Hokkaido, Japan
- Cleavage of the NS2-3 protein in the cells of cattle persistently infected with non-cytopathogenic bovine viral diarrhea virus
- Genetic and Pathobiological Characterization of Bovine Viral Diarrhea Viruses Recently Isolated from Cattle in Japan
- A Rapid and Highly Sensitive Method for Diagnosis of Equine Influenza by Antigen Detection Using Immuno-PCR
- Antigenic Variation Among Equine H 3 N 8 Influenza Virus Hemagglutinins
- Pseudorabies virus early protein 0 transactivates the viral gene promoters
- Mapping of a functional region conferring nuclear localization of pseudorabies virus immediate-early protein
- Interspecies Transmission and Receptor Recognition of Influenza A Viruses
- Serological Evidence of Leptospiral Infection in Pig Populations in Different Districts in Japan
- An H9N2 Influenza Virus Vaccine Prepared from a Non-Pathogenic Isolate from a Migratory Duck Confers Protective Immunity in Mice against Challenge with an H9N2 Virus Isolated from a Girl in Hong Kong
- Molecular Characterization of the Hemagglutinin and Neuraminidase Genes of H5N1 Influenza A Viruses Isolated from Poultry in Vietnam from 2004 to 2005
- Development and evaluation of indirect enzyme-linked immunosorbent assay for a screening test to detect antibodies against classical swine fever virus
- Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner
- Recovery of Leptospires from Miniature Pigs Experimentally Infected with Leptospira interrogans Serovar Manilae Strain UP-MMC under Immunosuppressive Conditions by Dexamethasone
- Characteristics of Influenza Virus Genome Mutations