Encephalitis in Mice Inoculated Intranasally with an Influenza Virus Strain Originated from a Water Bird.

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概要

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• Five-week-old ddY mice were inoculated intranasally with a low virulent (4e) or highly virulent (24a5b) avian influenza virus strain originated from a water bird. None of mice in the 4e group showed clinical signs and brain lesions. Of the 24a5b group, two mice died and one mouse was killed at a moribund state at day 7 post-inoculation (PI). Four mice of the 24a5b group necropsied at day 5 or 7 PI had mild to severe encephalitis in the brain stem and the cerebellar white matter. Influenza virus antigen was detected in neurons, glial cells and vascular endothelium in the lesions. The distribution of the lesions seems to indicate the transneuronal invasion of the virus via cranial nerve fibers into the brain.

• 公益社団法人 日本獣医学会の論文

著者

• MORITA Takehito

  Department of Veterinary Pathology, Tottori University

• OTSUKI Koichi

  Department of Veterinary Public Health, Faculty of Agriculture, Tottori University

• Otsuki Koichi

  Department Of Hygiene And Microbiology Faculty Of Veterinary Medicine Hokkaido University

• Umemura Takashi

  Department Of Cardiovascular Physiology And Medicine Hiroshima University Graduate School Of Biomedi

• Shimada Akinori

  Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University

• Nakajima Mie

  Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University

• ITO Toshihiro

  Department of Advanced Materials Science, Faculty of Engineering, Kagawa University

• MORITA Takehito

  Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan

• SILVANO Florence

  Department of Veterinary Pathology, Tottori University

• SHINYA Kyoko

  Department of Veterinary Pathology, Tottori University

• SHINYA Kyoko

  Department of Veterinary Pathology, Faculty of Agriculture, Tottori University

• Umemura Takashi

  Department of Applied Chemistry, Faculty of Engineering, Nagoya University

• UMEMURA Takashi

  Department of Veterinary Pathology, Tottori University

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