Characterization of the Chicken PKR : Polymorphism of the gene and Antiviral Activity against Vesicular Stomatitis Virus
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概要
- 論文の詳細を見る
The double-stranded RNA-dependent protein kinase (PKR) is induced in mouse and human cells on treatment with interferon．In this study, we have cloned and determined the nucleotide sequences of chicken PKR cDNA in various chicken breeds. Chicken PKR was a 550-amino-acid protein as deduced from the cDNA open reading frame (ORF), and there were specific domains (two double-stranded RNA binding domains (DRBDs) and numerous kinase subdomains) characterized in RNA binding proteins and kinase families. Furthermore, it was suggested that chicken PKR was polymorphic. Transfected cell clones expressing chicken PKR mRNA were demonstrated to confer antiviral responses to vesicular stomatitis virus, except for Koshamo type-3 (KS-3). KS-3 PKR, which has an amino acid substitution at position 507 (Arg to Gln), showed amphibious antiviral responses. This specific amino acid substitution was considered to determine the antiviral function of chicken PKR in addition to essential domains as DRBDs and kinase subdomains.
- 北海道大学の論文
- 2004-02-27
著者
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KON Yasuhiro
Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido Universi
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Asano Atsushi
Laboratory of Veterinary Biochemistry, Faculty of Agriculture, Tottori University
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Kon Yasuhiro
Laboratory Of Anatomy Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokka
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Watanabe Takafumi
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Asano Atsushi
Laboratory Of Experimental Animal Science Graduate School Of Veterinary Medicine Hokkaido University
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Asano Atsushi
Mobile Computing And Communications Development Center Digital Media Equipment And Services Company
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Asano Atsushi
Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine
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Watanabe Tomomasa
Laboratory Of Experimental Animal Science Graduate School Of Veterinary Medicine Hokkaido University
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Asano Atsushi
北海道大学 獣医学研究科動物疾病制御学講座実験動物学
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Ko Jae-hong
Laboratory Of Experimental Animal Science Department Of Disease Control Graduate School Of Veterinar
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Agui Takashi
Laboratory Of Laboratory Animal Science And Medicine Department Of Disease Control Graduate School O
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Tachi Atsushi
Laboratory Of Public Health Graduate School Of Veterinary Medicine Hokkaido University
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Watanabe T
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Watanabe Tomomasa
Animal Breeding and Reproduction, Graduate School of Agriculture, Hokkaido University
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Agui T
Laboratory Of Laboratory Animal Science And Medicine Department Of Disease Control Graduate School O
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Kon Yasuhiro
Laboratory Of Anatomy Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokka
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