Anatomic Modifications in the Enteric Nervous System of JF1 Mice with the Classic Piebald Mutation

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概要

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• The Japanese Fancy Mouse 1 (JF1) has a characteristic coat color similar to a very old mutant, <i>piebald</i>. The mutation in JF1 and the classic piebald was previously thought to be the same recessive allele in the endothelin B receptor gene (<i>Ednrb</i>) according to the haplotype pattern, which is insufficient for this conclusion. In this study, we identified the same insertion of a retroposon-like element in intron 1 of the <i>Ednrb</i> gene in JF1 as in the classic <i>piebald</i> mutation by PCR. Further, we investigated whether the intestine shows neuronal intestinal malformations such as hypoganglionosis and immaturity of ganglion cells by histochemical staining. Though it has been assumed that the defect of neural crest-derived lineages is restricted to melanocytes in JF1, we found that the enteric innervation and neuronal density were impaired throughout the whole colon in JF1 mice.<br>

著者

• Agui Takashi

  Laboratory Of Laboratory Animal Science And Medicine Department Of Disease Control Graduate School O

• SASAKI Nobuya

  Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido Universi

• TORIGOE Daisuke

  Laboratory of Laboratory Animal Science and Medicine, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University

• SASAKI Nobuya

  Laboratory of Laboratory Animal Science and Medicine, Graduate School of Veterinary Medicine, Hokkaido University

• DANG Ruihua

  Laboratory of Laboratory Animal Science and Medicine, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University

• DANG Ruihua

  Laboratory of Laboratory Animal Science and Medicine, Graduate School of Veterinary Medicine, Hokkaido University

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