High-Resolution Linkage Mapping of the Rat Hooded Locus
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概要
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To identify a gene responsible for the hooded phenotype in the rat, high-resolution linkage mapping for the hooded locus was performed using IS (non-hooded) and LEA (hooded) rats. The map revealed that only Kit gene existed in the critical region, suggesting that the Kit is a strong candidate gene. However, mutation was not found in the coding region of the LEA rat Kit gene. Further, the expressions of Kit mRNA were not different in fetal neural tubes and both neonatal and adult skins between IS and LEA rats. Furthermore, Kit-positive cells, possibly melanocytes, were found in the non-pigmented hair follicles of hooded phenotype rats. Several hypotheses are conceivable to account for mechanisms in the appearance of hooded phenotype.
著者
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Kon Yasuhiro
Laboratory Of Anatomy Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokka
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Okano Shinya
Laboratory Of Experimental Animal Science Depertment Of Disease Control School Of Veterinary Medicin
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Agui Takashi
Laboratory Of Laboratory Animal Science And Medicine Department Of Disease Control Graduate School O
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SASAKI Nobuya
Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido Universi
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ICHII Osamu
Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Ho
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TORIGOE Daisuke
Laboratory of Laboratory Animal Science and Medicine, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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DANG Ruihua
Laboratory of Laboratory Animal Science and Medicine, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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OHNAKA Takayuki
Laboratory of Laboratory Animal Science and Medicine, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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ICHII Osamu
Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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