Expression and distribution of inducible nitric oxide synthase in mouse testis
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概要
- 論文の詳細を見る
Nitric oxide (NO) is a simple and relatively unstable radical under physiological conditions. It is synthesized by three isoforms of NO synthase, that is neuronal, endothelial and inducible (iNOS) isoforms. In the present study, we investigated the distribution of iNOS with immunohistochemical methods in the mouse testis. The iNOS-immunoreactivity was detected on the basal region of the seminiferous tubules, where the cytoplasm of Sertoli cells was selectively immunolabeled. This immunoreactivity was observed by both immunofluorescent and immunoenzyme methods. Weak immunoreactivity was detected on the perinuclear cytoplasm of Sertoli cells throughout the seminiferous stages, whereas in stages I-VIII, it was remarkable on the processes of Sertoli cells surrounding the spermatogonia and early spermatocytes, and elongating into the lumina of seminiferous tubules. By reverse transcriptase-polymerase chain reaction, mRNA for iNOS was found to be expressed in the mouse testis. These results reveal that iNOS is consistently distributed at the front of the testicular environment.
- 北海道大学の論文
- 2002-11-29
著者
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Kon Yasuhiro
Laboratory Of Anatomy Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokka
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Kon Yasuhiro
Laboratory Of Anatomy Graduate School Of Veterinary Medicine Hokkaido University
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ENDOH Daiji
Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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Endoh Daiji
Faculty Of Veterinary Medicine Hokkaido Univ.
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Namiki Yuka
Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido Universi
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Kon Yasuhiro
Laboratory Of Anatomy Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokka
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ENDOH Daiji
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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NAMIKI Yuka
Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University
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