Identifying a new locus that regulates the development of rete ovarian cysts in MRL/MpJ mice
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MRL/MpJ (MRL) is a mouse model for autoimmune disease and develops ovarian cysts withage. The ovarian cysts originate from the rete ovarii, which is considered to be the remnantof fetal mesonephric tubules. In a previous study, we analyzed the genetic background ofovarian cysts by using backcross progenies between MRL and C57BL/6N (B6) mice. Byinterval mapping, suggestive linkages were detected on several chromosomes (Chrs), and asignificant linkage on Chr 14 was designated as MRL Rete Ovarian Cyst (mroc).In the present study, which evaluated 113 F2 intercross progenies, a significant linkageappeared on Chr 6 at the marker position D6Mit188 (likelihood ratio statistic ＝ 18.5). Inparticular, the peak regions of Chrs 6 and 14, which contain major causative loci bybackcross analysis, showed close reverse interaction. From these results, a locus on Chr 6was identified as mroc2, the second major locus associated with ovarian cyst formation in MRL mice.
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