Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome
スポンサーリンク
概要
- 論文の詳細を見る
The ICGN mouse is a model for nephrotic syndrome (NS) which presents with proteinuria, hyperlipidemia, and edema. In this study we attempted to identify the gene(s) responsible for NS. By analyzing albuminuria in 160 (ICGN × MSM)F1 × ICGN backcross progenies, we found that NS in the ICGN mouse is caused by more than one gene. We then performed a quantitative trait locus (QTL) analysis and detected a QTL with a very high LOD score peak in the telomeric region of Chr 15. By analyzing the nucleotide sequence of 22 genes located close to the QTL, we found that the tensin2 gene of the ICGN mouse possessed an 8-nucleotide deletion mutation in exon 18, leading to a frameshift and giving rise to a terminal codon at a premature position. Analyses of in situ hybridization and immunohistochemistry revealed that tensin2 was expressed in podocytes and tubular epithelial cells in normal mice but not in the ICGN mouse. These data raise the possibility that a mutation of the tensin2 gene is responsible for NS of the ICGN mouse and tensin2 is a prerequisite for the normal kidney function.
- Springerの論文
- 2006-05-01
著者
-
Asano Atsushi
Laboratory Of Experimental Animal Science Graduate School Of Veterinary Medicine Hokkaido University
-
Asano Atsushi
Mobile Computing And Communications Development Center Digital Media Equipment And Services Company
-
Asano Atsushi
北海道大学 獣医学研究科動物疾病制御学講座実験動物学
-
Tachi Atsushi
Laboratory Of Public Health Graduate School Of Veterinary Medicine Hokkaido University
-
Agui T
Laboratory Of Laboratory Animal Science And Medicine Department Of Disease Control Graduate School O
-
Kon Yasuhiro
Laboratory Of Anatomy Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokka
関連論文
- Structural characteristics of goat (Capra hircus) parotid salivary glands
- Genetic analysis of modifiers for the hooded phenotype in the rat
- Local overexpression of interleukin-1 family, member 6 relates to the development of tubulointerstitial lesions
- Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice
- Generation of congenic mouse strains by introducing the virus-resistant genes, Mx1 and Oas1b, of feral mouse-derived inbred strain MSM/Ms into the common strain C57BL/6J
- Characterization and epitope mapping of monoclonal antibodies to the nucleocapsid protein of severe acute respiratory syndrome coronavirus
- Polymorphism in MRL and AKR mice Sry : a candidate gene for the appearance of testicular oocyte
- Quantitative and Qualitative Urinary Cellular Patterns Correlate with Progression of Murine Glomerulonephritis
- Intracellular production of adrenal renin in the fetal mouse. An immuno-electron microscopic study
- HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES ON THE LOCALIZATION OF IMMUNOGLOBULINS IN PORCINE PLACENTA
- LIGHT AND ELECTRON MICROSCOPIC STUDIES ON CHICKEN INTESTINAL GLOBULE LEUCOCYTES
- BLOOD SUPPLY AND MICROVASCULATURE OF THE LYMPH NODES IN PIGS
- A SCANNING ELECTRON MICROSCOPIC STUDY ON THE ARCHITECTURE OF LYMPH VESSELS AND INTRANODAL LYMPH PATHWAYS OF LYMPH NODES IN PIGS
- Analysis of factors decreasing testis weight in MRL mice
- Quantitative trait locus analysis of ovarian cysts derived from rete ovarii in MRL/MpJ mice
- Epizootiological and Epidemiological Study of Hantavirus Infection in Japan
- Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model
- Strain differences of cerebral ventricles in mice: Can the MRL/MpJ mouse be a model for hydrocephalus?
- AN IMMUNOHISTOCHEMICAL STUDY OF THE GASTRO-ENTERO-PANCREATIC ENDOCRINE CELLS IN THE ALIMENTARY TRACT OF THE KOREAN TREE SQUIRREL, SCIURUS VULGARIS COREA
- Developmental study of the different effects on the hybrid sterility of Kit^W and Kit^ alleles paired with Kit^S from Mus spretus
- Upregulation of renal renin-angiotensin system in mouse diabetic nephropathy
- Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr（jumbled spine and ribs）mouse
- A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for the T-helper immunodeficiency (thid) in the LEC rat
- Characterization of the Chicken PKR : Polymorphism of the gene and Antiviral Activity against Vesicular Stomatitis Virus
- Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1
- A mutation in Tpst2 encoding tyrosylprotein sulfotransferase causes dwarfism associated with hypothyroidism.
- Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome
- Iterative Processing for Improving Decode Quality in Mobile Multimedia Communications (Special Section on Information Theory and Its Applications)
- Abnormal Splicing of the Endothelin Type B Receptor mRNA in the Aganglionosis Rat
- Analysis of the cell cycle of fibroblasts derived from the LEC rat after X-irradiation
- Genetic Association between Low Expression Phenotype of CD62L (L-selectin) in Peripheral CD4^+ T Cells and the thid (T-helper Immunodeficiency) Phenotype in the LEC Rat
- Linkage Mapping of the Rat 8-Oxoguanine DNA Glycosylase Gene to Chromosome 4
- X-ray Hypersensitivity in the LEA Rat: Genetic Linkage Analysis of Responsible Loci
- Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice
- Distribution of neutral amino acid transporter ASCT1 in the non-neuronal tissued of mice
- Identifying a new locus that regulates the development of rete ovarian cysts in MRL/MpJ mice
- Genetic Background Strongly Modifies the Severity of Symptoms of Hirschsprung Disease, but not Hearing Loss in Rats Carrying Ednrb^[sl] Mutations
- Female Infertility in grt Mice is Caused by Thyroid Hormone Deficiency, not by Insufficient TPST2 Activity in the Reproductive Organs(Laboratory Animal Science)
- Exon skipping of exonuclease 1 in MRL/MpJ mice is caused by a nucleotide substitution of the branchpoint sequence in intron eight
- Identification of antigenic peptides derived from B-cell epitopes of nucleocapsid protein of mouse hepatitis virus for serological diagnosis
- IMMUNOHISTOCHEMICAL DEMONSTRATION OF JUXTAGLOMERULAR CELLS IN THE KIDNEYS OF DOMESTIC MAMMALS AND FOWLS
- Expression and distribution of inducible nitric oxide synthase in mouse testis
- Comparative study of renin expression in the coagulating glands of C57BL/6 and Balb/c mice
- Effect of Paramagnetic Fe^ on T_1^H in PVA/montmorillonite-clay Nanocomposites
- QTL Analysis Identifies a Modifier Locus of Aganglionosis in the Rat Model of Hirschsprung Disease Carrying Ednrb^[sl] Mutations
- Molecular Pathology of Murine Ureteritis Causing Obstructive Uropathy with Hydronephrosis
- Identifying Quantitative Trait Loci Affecting Resistance to Congenital Hypothyroidism in 129^[+Ter]/SvJcl Strain Mice
- The chicken 2'-5' oligoadenylate synthetase A inhibits the replication of West Nile Virus
- Identification of genetic loci affecting the establishment and development of Echinococcus multilocularis larvae in mice