X-ray Hypersensitivity in the LEA Rat: Genetic Linkage Analysis of Responsible Loci
スポンサーリンク
概要
- 論文の詳細を見る
The LEA rat was established from a Long-Evans rat closed colony as the control strain of the LEC rat, which is reported to exhibit several mutant phenotypes such as hepatic disorder (hts), blockage of the T cell differentiation (thid) and X-ray hypersensitivity (xhs1 and xhs2). Here we report that the LEA rat is hypersensitive to X-rays to a similar degree as the LEC rat, although it is normal with respect to the hts and thid phenotypes. We further performed genetic linkage analysis of X-ray hypersensitivity in the LEA rat. The quantitative trait loci (QTL) linkage analysis revealed that xhs1 but not xhs2 is the locus responsible for X-ray hypersensitivity in the LEA rat.
- 社団法人 日本実験動物学会の論文
著者
-
Tachi Atsushi
Laboratory Of Public Health Graduate School Of Veterinary Medicine Hokkaido University
-
MIYAMOTO Tomomi
Center for Experimental Animal Science, Nagoya City University Medical School
-
TSUMAGARI Takashi
KAC Co., LTD.
-
AGUI Takashi
Center for Experimental Animal Science, Nagoya City University Medical School
-
Agui T
Laboratory Of Laboratory Animal Science And Medicine Department Of Disease Control Graduate School O
-
Tsumagari Takashi
Kac Co. Ltd.
関連論文
- Genetic analysis of modifiers for the hooded phenotype in the rat
- Generation of congenic mouse strains by introducing the virus-resistant genes, Mx1 and Oas1b, of feral mouse-derived inbred strain MSM/Ms into the common strain C57BL/6J
- Characterization and epitope mapping of monoclonal antibodies to the nucleocapsid protein of severe acute respiratory syndrome coronavirus
- Epizootiological and Epidemiological Study of Hantavirus Infection in Japan
- Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model
- Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr（jumbled spine and ribs）mouse
- A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for the T-helper immunodeficiency (thid) in the LEC rat
- Characterization of the Chicken PKR : Polymorphism of the gene and Antiviral Activity against Vesicular Stomatitis Virus
- A mutation in Tpst2 encoding tyrosylprotein sulfotransferase causes dwarfism associated with hypothyroidism.
- Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome
- Abnormal Splicing of the Endothelin Type B Receptor mRNA in the Aganglionosis Rat
- Analysis of the cell cycle of fibroblasts derived from the LEC rat after X-irradiation
- Genetic Association between Low Expression Phenotype of CD62L (L-selectin) in Peripheral CD4^+ T Cells and the thid (T-helper Immunodeficiency) Phenotype in the LEC Rat
- Linkage Mapping of the Rat 8-Oxoguanine DNA Glycosylase Gene to Chromosome 4
- X-ray Hypersensitivity in the LEA Rat: Genetic Linkage Analysis of Responsible Loci
- Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice
- An Optimum Design of FIB System with a Beam Crossover : Techniques, Instrumentations and Measurement
- Analysis of Mechanical Aberrations in the Eleclrostatic Deflector
- Genetic Background Strongly Modifies the Severity of Symptoms of Hirschsprung Disease, but not Hearing Loss in Rats Carrying Ednrb^[sl] Mutations
- Female Infertility in grt Mice is Caused by Thyroid Hormone Deficiency, not by Insufficient TPST2 Activity in the Reproductive Organs(Laboratory Animal Science)
- Exon skipping of exonuclease 1 in MRL/MpJ mice is caused by a nucleotide substitution of the branchpoint sequence in intron eight
- Identification of antigenic peptides derived from B-cell epitopes of nucleocapsid protein of mouse hepatitis virus for serological diagnosis
- QTL Analysis Identifies a Modifier Locus of Aganglionosis in the Rat Model of Hirschsprung Disease Carrying Ednrb^[sl] Mutations
- Identifying Quantitative Trait Loci Affecting Resistance to Congenital Hypothyroidism in 129^[+Ter]/SvJcl Strain Mice
- The chicken 2'-5' oligoadenylate synthetase A inhibits the replication of West Nile Virus
- Identification of genetic loci affecting the establishment and development of Echinococcus multilocularis larvae in mice