Wortmannin, a Radiation Sensitizer, Enhances the Radiosensitivity of WKAH Rat Cells but not That of LEC Rat Cells.
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概要
- 論文の詳細を見る
No significant cytotoxic effect was observed in WKAH rat cells by the treatment of wortmannin, a radiation sensitizer, at concentrations lower than 30 μM for 24 hr. The relative surviving fractions of LEC rat cells were slightly, but significantly, lower than those of WKAH rat cells at each concentration of wortmannin. When the wortmannin-treated WKAH rat cells were X-irradiated, the relative surviving fractions decreased in a wortmannin concentration-dependent manner. On the contrary, no significant difference was observed between the survival curves of untreated and wortmannin-treated LEC rat cells after X-irradiation.
- 公益社団法人 日本獣医学会の論文
著者
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OKUI Toyo
Hokkaido Institute of Public Health
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ENDOH Daiji
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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HAYASHI Masanobu
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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KAWANA Ai
Department of Veterinary Radiology, Faculty of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069-8501, Japan
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- Wortmannin, a Radiation Sensitizer, Enhances the Radiosensitivity of WKAH Rat Cells but not That of LEC Rat Cells.