RESTRICTION FRAGMENT LENGTH POLYMORPHISM FOR THE YC SUBUNIT GENE OF RAT LIVER GLUTATHIONE S-TRANSFERASE
スポンサーリンク
概要
- 論文の詳細を見る
An altered expression of the Yc subunit gene of rat glutathione S-transferase (GST) in the liver of the LEC rat, which is a mutant strain with spontaneous hereditary hepatitis associated with severe jaundice, has been reported. To provide further information concerning the structure of the Yc subunit gene, we carried out the Southern blot hybridization analysis of DNA samples from rats of eight different inbred strains including LEC with cDNA complementary to mRNA specific for the Yc subunit of rat liver GST as a probe. The hybridization patterns of the DNA samples from rats belonging to the different inbred strains showed interstrain variation in the length of restriction fragments with four restriction endonucleases. Since the DNA samples prepared from several rats of one inbred strain gave an identical hybridization pattern, the restriction fragment patterns for the Yc gene could be used as markers for genetic monitoring of inbred rat strains. Although the altered expression of Yc-Yc activity of GST has been observed in the liver of the LEC rat, the characteristic changes in the gene structure of the Yc subunit of LEC rat were not detected in the present hybridization analysis.
- 北海道大学の論文
- 1990-07-20
著者
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Sasaki Yasuhiko
Department Of Internal Medicine Ishinomaki Red Cross Hospital
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Sasaki Yasuhiko
Department Of Laboratory Animal Science Faculty Of Veterinary Medicine Hokkaido University
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HAYASHI Masanobu
Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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Namioka S
Zen‐noh Inst. Animal Health Chiba Jpn
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Namioka Shigeo
Department Of Laboratory Animal Science Faculty Of Veterinary Medicine Hokkaido University
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Hayashi Masanobu
Department Of Experimental Radiobiology Faculty Of Veterinary Medicine Hokkaido University
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MATSUMOTO Kouzou
Institute of Animal Experimentation, University of Tokushima School of Medicine
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Matsumoto Kouzou
Institute Of Animal Experimentation University Of Tokushima School Of Medicine
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Hayashi Masanobu
Department Of Veterinary Radiology School Of Vterinary Medicine Rakuno Gakuen University
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SASAKI Yasuhiko
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Hokkaido University
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HAYASHI Masanobu
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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