Hepatic iron Accumulation Is Not Directly Associated with Induction of DNA Strand Breaks in the Liver Cells of Long-Evans Cinnamon (LEC) Rats
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概要
- 論文の詳細を見る
肝炎を自然発症するLECラットにおいてDNA単鎖切断に及ぼす銅の蓄積の影響を調べた。LECラットの肝臓において銅と鉄は4週齢から15週齢に蓄積した。低鉄食で飼育したラットでは鉄の蓄積は認められなかったが、銅の蓄積は普通食のラットと同様量認められた。肝細胞のDNA単鎖切断の量はcomet法を用いて検出した。テールが認められた細胞の頻度とテールの長さの平均値を求めたところ、低鉄食を与えたLECラットの肝細胞と普通食を与えたLECラットの間にほとんど違いは認められなかった。これらの結果からLECラットの肝細胞におけるDNA損傷の誘発には鉄の蓄積は関与していないことが示唆された。
著者
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有川 二郎
北海道大学医学部附属動物実験施設
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ARIKAWA Jiro
Institute of Immunological Science, Hokkaido University
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有川 二郎
北海道大学 大学院医学研究科微生物学講座
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ARIKAWA Jiro
Hokkaido University School of Medicine
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Arikawa Jiro
ベトナム
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Jiro Arikawa
Institute For Animal Experimentation School Of Medicine Hokkaido University
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Arikawa Jiro
Institute For Animal Experimentation School Of Medicine Hokkaido University
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Arikawa Jiro
Institute For Animal Experimentation Hokkaido University Graduate School Of Medicine
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Nakayama K
Hokkaido Institute Of Public Health
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HAYASHI Masanobu
Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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ENDOH Daiji
Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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NAKAYAMA Kenji
Hokkaido Institute of Public Health
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OKUI Toyo
Hokkaido Institute of Public Health
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KUGE Tomoko
Department of Veterinary Radiology, School of Vterinary Medicine, Rakuno Gakuen University
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TAKAZAWA Akira
Biophysics Laboratory, Institute for Electronic Science, Hokkaido University
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Okui Toyo
酪農学園大学 獣医学部獣医放射線生物学
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Kuge Tomoko
Department Of Veterinary Radiology School Of Vterinary Medicine Rakuno Gakuen University
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Endoh Daiji
Faculty Of Veterinary Medicine Hokkaido Univ.
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Takazawa Akira
Biophysics Laboratory Institute For Electronic Science Hokkaido University
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Hayashi Masanobu
Department Of Experimental Radiobiology Faculty Of Veterinary Medicine Hokkaido University
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Arikawa J
Inst. For Animal Experimentation Hokkaido Univ. Graduate School Of Medicine
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Hayashi Masanobu
Department Of Veterinary Radiology School Of Vterinary Medicine Rakuno Gakuen University
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ENDOH Daiji
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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HAYASHI Masanobu
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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