Epizootiological survey of hantavirus among rodent species in Ningxia Hui Autonomous Province, China
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概要
- 論文の詳細を見る
Hantaviral antibodies were detected in the sera from Apodemus (A.) agrarius and A. peninsulae captured in Ningxia province, China by several different serological diagnostic methods. A total of 409 sera from rodent and insectivore species were collected in 1999 and examined by indirect immunofluorescent antibody assay (IFA). Among them, 19 of 191 (9.9%) sera of A. agrarius and 1 of 13 (7.7%) sera of A. peninsulae were positive for hantaviral antibodies. The other species (Rattus norvegicus, Mus musculus, Cricetulus triton, and Sorex cylindricauda) were negative. The reaction pattern of positive serum was characterized as scattered and granular virus antigens in the cytoplasm of hantavirus infected Vero E6 cells. Some of the A. agrarius sera positive for hantavirus were further examined by Western blotting (WB), enzyme-linked immunosorbent assay (ELISA), and the focus reduction neutralization test (FRNT). By WB, positive sera showed the same specific reaction pattern of baculovirus-expressed recombinant hantaviral nucleocapsid protein, as shown in hantavirus-immune serum. By ELISA, IFA-positive sera showed significantly higher optical densities (around 1.0) than the negative A. agrarius sera. Hantaan type hantavirus was neutralized with the positive sera. These results suggest that A. agrarius have hantavirus infection and may play a role as a reservoir animal for hantavirus in Ningxia Hui Autonomous Province, China.
- 北海道大学の論文
- 2001-08-31
著者
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有川 二郎
北海道大学医学部附属動物実験施設
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Itoh T
Iclas Monitoring Center Central Institute For Experimental Animals
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Kumada Hiromitsu
国家公務員共済組合連合会虎の門病院 肝臓内科
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Cui Bai
Laboratory Of Public Health Graduate School Of Veterinary Medicine Hokkaido University:qinghai Insti
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Kariwa Hiroaki
Hokkaido Univ. Sapporo Jpn
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Kariwa Hiroaki
Laboratory Of Public Health Department Of Environmental Veterinary Sciences Graduate School Of Veter
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Murphy Michael
Laboratory Of Public Health Graduate School Of Veterinary Medicine Hokkaido University
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Araki Koichi
Laboratory Of Public Health Department Of Environmental Veterinary Sciences Faculty Of Veterinary Me
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TAKASHIMA Ikuo
Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Vet
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ARIKAWA Jiro
Institute of Immunological Science, Hokkaido University
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YOSHIMATSU Kumiko
Institute of Immunological Science, Hokkaido University
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MIZUTANI Tetsuya
Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Vet
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有川 二郎
北海道大学 大学院医学研究科微生物学講座
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Takashima Ikuo
Laboratory Of Public Health Department Of Environmental Veterinary Sciences Graduate School Of Veter
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ARIKAWA Jiro
Hokkaido University School of Medicine
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Arikawa Jiro
ベトナム
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Jiro Arikawa
Institute For Animal Experimentation School Of Medicine Hokkaido University
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Arikawa Jiro
Institute For Animal Experimentation School Of Medicine Hokkaido University
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Arikawa Jiro
Institute For Animal Experimentation Hokkaido University Graduate School Of Medicine
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LOKUGAMAGE Nandadeva
Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University
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LOKUGAMAGE Kumari
Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University
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FUKUSHIMA Hiroshi
Shimane Prefectural Institute of Public Health and Environment Science
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HU Xiong
Sanitation and Antiepidemic Station of Ningxia
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CHEN Jiehua
Sanitation and Antiepidemic Station of Ningxia
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Takashima I
Hokkaido Univ. Sapporo Jpn
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Murphy Michael
Laboratory For Reactor Physics And Systems Behaviour Paul Scherrer Institute
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Fukushima Hiroshi
Shimane Prefectural Institute Of Public Health And Environmental Science
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Mizutani T
Transdisciplinary Life Science Course Faculty Of Advanced Life Science Hokkaido University
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Mizutani Tetsuya
Virology Division National Cancer Center Research Institute
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Takashima Ikuo
Hokkaido Univ. Hokkaido Jpn
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Arikawa J
Inst. For Animal Experimentation Hokkaido Univ. Graduate School Of Medicine
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Fukushima H
Shimane Prefectural Institute Of Public Health And Environmental Science
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Koga Hiroyuki
Department Of Hepatology Toranomon Hospital
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Mizutani Tetsuya
Laboratories Of Public Health Hokkaido University
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Yoshimatsu Kumiko
Institute For Animal Experimentation Hokkaido University Graduate School Of Medicine
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Lokugamage Kumari
Laboratory Of Public Health Graduate School Of Veterinary Medicine Hokkaido University
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Kariwa H
Hokkaido Univ. Sapporo Jpn
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Lokugamage Nandadeva
Laboratory Of Public Health Graduate School Of Veterinary Medicine Hokkaido University
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Araki Koichi
Laboratory of Chemistry for Natural Products, Faculty of Science, Tokyo Institute of Technology
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