Genetic and biological comparision of tick-borne encephalitis viruses from Hokkaido and Far-Eastern Russia
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概要
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We compared the biological properties of Oshima 5-10 (tick-borne encephalitis [TBE] virus isolated in Hokkaido, Japan) and Sofjin-HO (Far-Eastern subtype TBE virus) including plaque formation, virus replication and virus protein synthesis in BHK-21 cell cultures to reveal strain differences. We also determined the complete nucleotide sequences of both strains and compared the deduced amino acid sequences. Plaques of Oshima 5-10 were smaller than those of Sofjin-HO. Virus titers in culture fluid of Oshima 5-10 were 1/100 of those of Sofjin-HO at 9 and 12 hr after infection. Less viral protein and RNA syntheses of strain Oshima 5-10 was observed than with Sofjin-HO. Genetic analysis revealed 1.4% of amino acids to differ with Sofjin-HO. No difference between the two strains was detected in the motif sequence of the viral enzyme, cleavage sites of viral protein or glycosylation sites of NS1.
- 北海道大学の論文
- 2002-02-28
著者
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Itoh T
Iclas Monitoring Center Central Institute For Experimental Animals
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Kumada Hiromitsu
国家公務員共済組合連合会虎の門病院 肝臓内科
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Kariwa Hiroaki
Hokkaido Univ. Sapporo Jpn
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Kariwa Hiroaki
Laboratory Of Public Health Department Of Environmental Veterinary Sciences Graduate School Of Veter
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MIZUTANI Tetsuya
Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Vet
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HAYASAKA Daisuke
Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Vet
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TAKASHIMA Ikuo
Graduate School of Veterinary Medicine, Hokkaido University
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Takashima I
Hokkaido Univ. Sapporo Jpn
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Hayasaka Daisuke
Laboratory Of Public Health Department Of Environmental Veterinary Sciences Graduate School Of Veter
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Mizutani T
Transdisciplinary Life Science Course Faculty Of Advanced Life Science Hokkaido University
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Mizutani Tetsuya
Virology Division National Cancer Center Research Institute
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Goto Akiko
Laboratory Of Public Health Department Of Environmental Veterinary Sciences School Of Veterinary Med
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YOSHII Kentarou
Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University
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Takashima Ikuo
Hokkaido Univ. Hokkaido Jpn
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Yoshii Kentarou
Laboratory Of Public Health Department Of Environmental Veterinary Sciences School Of Veterinary Med
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Koga Hiroyuki
Department Of Hepatology Toranomon Hospital
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Mizutani Tetsuya
Laboratories Of Public Health Hokkaido University
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Kariwa H
Hokkaido Univ. Sapporo Jpn
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