Development of vaccine strains of H5 and H7 influenza viruses
スポンサーリンク
概要
- 論文の詳細を見る
To establish vaccine strains of H5 and H7 influenza viruses, A/duck/Hokkaido/Vac-1/04 (H5N1) [Vac-1/04 (H5N1)], A/duck/Hokkaido/Vac-3/07 (H5N1) [Vac-3/07 (H5N1)], and A/duck/Hokkaido/ Vac-2/04 (H7N7) [Vac-2/04 (H7N7)] were generated from non-pathogenic avian influenza viruses isolated from migratory ducks. Vac-1/04 (H5N1) and Vac-3/07 (H5N1) were generated by genetic reassortment between H5N2 or H5N3 virus as an HA gene provider and H7N1 or H6N1 viruses as an NA gene provider. Vac-2/04 (H7N7) was a genetic reassortant obtained using H7N7 and H9 N2 viruses to give high growth character of the H9N2 virus in chicken embryonated eggs. The results of sequence analyses and experimental infections revealed that these H5N1 and H7N7 reassortant viruses were non-pathogenic in chickens and embryos, and had good growth potential in embryonated eggs. These viruses should be useful to develop vaccines against H5 and H7 highly pathogenic avian influenza viruses.
- The Graduate School of Veterinary Medicine, Hokkaido Universityの論文
- 2008-02-09
著者
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Kumada Hiromitsu
冲中記念成人病研究所
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Kumada Hiromitsu
国家公務員共済組合連合会虎の門病院 肝臓科
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Kumada Hiromitsu
国家公務員共済組合連合会虎の門病院 肝臓内科
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Kariwa Hiroaki
Hokkaido Univ. Sapporo Jpn
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Kariwa Hiroaki
北海道大学 獣医研究科
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Kumada H
Department Of Hepatology Toranomon Hospital
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Sakoda Yoshihiro
Hokkaido Univ. Sapporo Jpn
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Sakamoto Ryuichi
Chemo‐sero‐therapeutic Res. Inst. Kikuchi
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Koga Hiroyuki
Department Of Hepatology Toranomon Hospital
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Yamauchi Hideto
Hokkaido Univ. Sapporo Jpn
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Kariwa H
Hokkaido Univ. Sapporo Jpn
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