Antigenic structure of the hemagglutinin of H9N2 influenza viruses.
スポンサーリンク
概要
- 論文の詳細を見る
The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs), respectively. Based on the reactivity patterns of these mutants with a panel of MAbs, at least 5 non-overlapping antigenic sites were defined using 8 MAbs which recognized 7 distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.
- Springer Wienの論文
著者
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Kumada Hiromitsu
冲中記念成人病研究所
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Kumada Hiromitsu
国家公務員共済組合連合会虎の門病院 肝臓科
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Kumada Hiromitsu
国家公務員共済組合連合会虎の門病院 肝臓内科
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Kariwa Hiroaki
Hokkaido Univ. Sapporo Jpn
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Kariwa Hiroaki
北海道大学 獣医研究科
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Kumada H
Department Of Hepatology Toranomon Hospital
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Sakoda Yoshihiro
Hokkaido Univ. Sapporo Jpn
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Kishida Noriko
Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University
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Koga Hiroyuki
Department Of Hepatology Toranomon Hospital
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Kariwa H
Hokkaido Univ. Sapporo Jpn
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