A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice
スポンサーリンク
概要
- 論文の詳細を見る
We examined whether a vesicular stomatitis virus (VSV) pseudotype bearing the hantavirus envelope glycoproteins (GPs) G1 and G2 (VSVÎ G*HTN) could be used as a safe and effective alternative to native hantavirus. Mice were immunized with purified particles of VSVÎ G*HTN. After the second immunization, all mice produced anti-GP antibody as detected in ELISA and a neutralization test. After the third immunization, the mice were challenged with Hantaan virus. Neither anti-NP antibody production nor Hantaan virus-specific CD8 T-cell reactions were detected in these mice. The present study demonstrated the potential of using a pseudotype VSV system as a tool for developing a hantavirus vaccine.
- Elsevierの論文
- 2006-04-05
著者
-
有川 二郎
北海道大学医学部附属動物実験施設
-
有川 二郎
北海道大学 大学院医学研究科微生物学講座
-
ARIKAWA Jiro
Hokkaido University School of Medicine
-
Arikawa Jiro
ベトナム
-
Jiro Arikawa
Institute For Animal Experimentation School Of Medicine Hokkaido University
-
Arikawa Jiro
Institute For Animal Experimentation School Of Medicine Hokkaido University
-
Arikawa Jiro
Institute For Animal Experimentation Hokkaido University Graduate School Of Medicine
-
NAKAMURA Ichiro
Graduate School of Veterinary Medicine, Hokkaido University
-
Arikawa J
Inst. For Animal Experimentation Hokkaido Univ. Graduate School Of Medicine
-
Okumura Megumi
Hokkaido Univ.
-
Lee Byoung‐hee
Hokkaido Univ.
関連論文
- ウイルス感染症 ハンタウイルス (広範囲 血液・尿化学検査 免疫学的検査(第7版・3)その数値をどう読むか) -- (免疫学的検査 感染症関連検査(抗原および抗体を含む))
- スナネズミへの接種によるPuumalaおよびPuumala関連ウイルスの効率的な回収方法の開発(公衆衛生学)
- 四塩化炭素誘導性肝薄書に対するリグナン含有亜麻仁油抽出物の防護効果(生化学)
- カイコ中に発現させた組換えハンタウイルス核蛋白を抗原としたウェスタンブロッティング(WB)法の人血清における血清学的確定診断への応用
- 腎症候性出血熱
- 異種動物赤血球のSCIDマウスへの定着とその排除
- LECラット胸腺細胞におけるX線誘発アポトーシス高感受性(実験動物学)
- Long-Evans Cinnamon(LEC)ラットの肝細胞には銅によって生成されるDNA鎖切断の量に雌雄差はみられない
- In vitroとIn vivoにおけるラクトフェリンとリバビリンのハンダウイルスに対する抗ウイルス活性の特徴
- Capture ELISA法による野外ラットにおけるボルナ病ウイルス抗体の検索
- 組み換えウイルス抗原を用いたラットにおけるボルナ病ウイルス感染診断(短報)
- 国動協および公私動協において動物実験に用いられたサルおよびブタのHEV感染調査
- SCIDマウスにおけるハンタウイルス感染
- Genetic and antigenic analyses of a Puumala virus isolate as a potential vaccine strain
- Characterization of the Mode of Hantaan Virus Infection in Adult Mice Using a Nested Reverse Transcriptase Polymerase Chain Reaction: Transient Virus Replication in Adult Mice
- Production of recombinant Hantavirus nucleocapsid protein expressed in silkworm larvae and its use as a diagnostic antigen in detecting antibodies in serum from infected rats
- Evidence for the existence of Puumula-related virus among Clethrionomys rufocanus in Hokkaido, Japan
- Characterization of the mode of Hantaan virus infection in adult mice using a nested reverse transcriptase polymerase chain reaction : transient virus replication in adult mice
- Comparison of nucleotide sequences of M genome segments among Seoul virus strains isolated from Eastern Asia
- Enhancement of infectivity of hantavirus in cell culture by
- Epizootiological studies of hantavirus infection among urban rats in Hokkaido, Japan: evidences for the persistent infection from the sero-epizootiological surveys and antigenic characterizations of hantavirus isolates.
- EFFECT OF NEUTRALIZING MONOCLONAL ANTIBODIES ON HANTAAN VIRUS INFECTION OF THE MACROPHAGE P388D1 CELL LINE
- ENZYME-LINKED IMMUNOSORBENT ASSAY FOR DETECTION OF ANTIBODY AGAINST HEMORRHAGIC FEVER WITH RENAL SYNDROME VIRUS IN SERA FROM EXPERIMENTALLY INFECTED RATS
- LABELED AVIDIN-BIOTIN ENZYME-LINKED IMMUNOSORBENT ASSAY (LAB-ELISA) FOR DETECTION OF JAPANESE ENCEPHALITIS ANTIBODY IN SWINE SERA
- 北海道のドブネズミにおけるハンタウイルス感染の流行病学的研究 : 血清疫学的調査とハンタウイルス分離株の抗原性の解析による持続感染の証拠
- 単クローン性抗体を用いたChlamydia psittaciの抗原解析
- 北海道のドバトとガラスにおけるクラミジアの分離と血清学的調査
- エマージング・リエマージング感染症(2)ハンタウイルスによる肺疾患
- 北海道大学大学院医学研究科附属動物実験施設(大学院比較医学講座)
- ハンタウイルス
- 組み換えバキュロウイルスで発現させたハンタウイルス核蛋白のIFA診断抗原への応用 : 腎症候性出血熱原因ウイルスの3種類の血清型との交差反応性(短報)
- Prevalence of Herpes B Virus Antibody in Nonhuman Primates reared at the National University of Japan
- Establishment of an Enzyme-Linked Immunosorbent Assay for Detection of Hantavirus Antibody of Rats Using a Recombinant of Nucleocapsid Protein Expressed in Escherichia coli
- ハンタウイルス肺症候群・腎症候性出血熱
- げっ歯類媒介性人獣共通感染症としてのハンタウイルス感染症対策
- 動物由来感染症としてのハンタウイルス感染症 : 腎症候性出血熱とハンタウイルス肺症候群
- ハンタウイルス感染症
- わが国の野生げっ歯類におけるハンタウイルス感染の疫学的研究と血清診断
- Detection of Hantaviral Antibodies among Patients with Hepatitis of Unknown Etiology in Japan
- Hepatic iron Accumulation Is Not Directly Associated with Induction of DNA Strand Breaks in the Liver Cells of Long-Evans Cinnamon (LEC) Rats
- Mode of Infection of Hokkaido Virus (Genus Hantavirus) among Grey Red-Backed Voles, Myodes rufocanus, in Hokkaido, Japan
- A comparative epidemiological study of hantavirus infection in Japan and Far East Russia
- Epizootiological and Epidemiological Study of Hantavirus Infection in Japan
- Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model
- Epizootiological survey of hantavirus among rodent species in Ningxia Hui Autonomous Province, China
- Microbiological Contamination in Genetically Modified Animals and Proposals for a Microbiological Test Standard for National Universities in Japan
- 国動協および公私動協において動物実験に用いられたサルおよびブタのHEV感染調査
- Protective effect of mucosal administration of recombinant human macrophage colony-stimulating factor (rhM-CSF) on mucosal infection of Sendai virus in mice.
- Effect of MDP-Lys(L18) as a mucosal immunoadjuvant on protection of mucosal infections by Sendai virus and rotavirus.
- Characterization of the nucleocapsid protein of Hantaan virus strain 76-118 using monoclonal antibodies.
- Effect of MDP-Lys(L18), a derivative of MDP, on enhancing host resistance against Hantaan virus infection in newborn mice.
- Effects of muramyl dipeptide derivatives as adjuvants on the induction of antibody response to recombinant hepatitis B surface antigen.
- Hantavirus Infection-typical rodent-borne viral zoonosis
- The Follow-Up Study of Swine and Hong Kong Influenza Virus Infection among Japanese Hogs
- Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides).
- A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice
- Epidemiology and Epizootiology of Hantavirus Infection in Japan
- Application of a recombinant baculovirus expressing hantavirus reactivities among 3 serotypes of hantavirus which causes hemorrhagic fever with renal syndrome (HFRS)
- Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts
- Evaluation of Serological Diagnosis of Borna Disease Virus Infection Using Recombinant Proteins in Experimentally Infected Rats.
- 新世界ハンタウイルス感染症の血清型鑑別診断のための組換え核蛋白を用いた新規ELISA法の開発
- ブニヤウイルスとその生態