Evaluation of Serological Diagnosis of Borna Disease Virus Infection Using Recombinant Proteins in Experimentally Infected Rats.

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概要

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• We produced two recombinant Borna disease virus (BDV) proteins, p40 and p24, by using a baculovirus vector as a diagnostic antigen. Antigenicities of these recombinant proteins were evaluated by immune rabbit sera. Recombinant p40 was a more sensitive antigen than p24 for the detection of antibodies in infected rats. Rats inoculated with BDV within 24 hr after birth showed higher detection rates of viral RNA and viral proteins from the brain than rats inoculated at 4 weeks-old. Depending on the age of infection and the time postinfection, the detection of BDV RNA, protein, or anti-BDV antibody did not always correlate in individuals. We suggest both serological and molecular biological methods are needed in the diagnosis of BDV infection.

• 公益社団法人 日本獣医学会の論文

著者

• Arikawa Jiro

  Institute For Animal Experimentation Hokkaido University Graduate School Of Medicine

• Ogino Michiko

  Laboratory Of Public Health Department Of Environmental Veterinary Sciences School Of Veterinary Med

• Tsujimura Kouji

  Laboratory Of Public Health Department Of Environmental Veterinary Sciences Faculty Of Veterinary Me

• Mizutani Tetsuya

  Laboratories Of Public Health Hokkaido University

• Yoshimatsu Kumiko

  Institute For Animal Experimentation Hokkaido University Graduate School Of Medicine

• ARIKAWA Jiro

  Institute for Animal Experimentation, School of Medicine, Hokkaido University

• YOSHIMATSU Kumiko

  Institute for Animal Experimentation, School of Medicine, Hokkaido University

• OGINO Michiko

  Laboratory of Public Health, Department of Environmental Veterinary Sciences

• TSUJIMURA Kouji

  Laboratory of Public Health, Department of Environmental Veterinary Sciences

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