Higher Sensitivity in Induction of Apoptosis in Fibroblast Cell Lines Derived from LEC Strain Rats to UV-Irradiation.
スポンサーリンク
概要
- 論文の詳細を見る
The proportion of S-phase cells in a WKAH rat cell population decreased and that of G1-phase cells increased at 8 and 18 hr post-incubation following UV-irradiation, although no significant change was observed in the ratio of the proportion of S-phase to G1-phase cells in a LEC rat cell population. Thus, UV-radiation-induced delay in the progression from the G1 to S phase was observed in WKAH rat cells but was not apparent in LEC rat cells. The fraction of LEC rat cells containing a sub-G0 DNA content increased with post-incubation time after UV-irradiation, but not that of WKAH rat cells. The proportion of the sub-G0 fraction in LEC rat cells increased with increasing doses of UV-rays. Low molecular weight DNAs extracted from UV-irradiated LEC rat cells exhibited an intense DNA ladder pattern at 18 and 24 hr post-irradiation by electrophoretic analysis, but not those from UV-irradiated WKAH rat cells. These results showed a higher sensitivity of LEC rat cells in induction of apoptosis than that of WKAH rat cells to UV-irradiation, although there was no difference in the survival curves among the cell lines from LEC and WKAH rats after UV-irradiation.
- 公益社団法人 日本獣医学会の論文
著者
-
ISOGAI Emiko
Department of Hygiene, Health Sciences University of Hokkaido
-
OKUI Toyo
Hokkaido Institute of Public Health
-
Arai Soichiro
Department Of Experimental Radiobiology Faculty Of Veterinary Medicine Hokkaido University
-
HAYASHI Masanobu
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
-
HAYASHI Masanobu
Department of Veterinary Radiology, Faculty of Veteriniary Medicine, Rakuno Gakuen University
-
UEHARA Kazuhisa
Department of Veterinary Radiology, Faculty of Veterinary Medicine, Rakuno Gakuen University
-
ICHIKAWA Yukako
Department of Veterinary Radiology, Faculty of Veteriniary Medicine, Rakuno Gakuen University
-
UEHARA Kazuhisa
Department of Veterinary Radiology, Faculty of Veteriniary Medicine, Rakuno Gakuen University
関連論文
- Combined Effect of Rebamipide and Ecabet Sodium on Helicobacter pylori Adhesion to Gastric Epithelial Cells
- Borrelia burgdorferi Sensu Lato in an Endemic Environment: Wild Sika Deer (Cervus nippon yesoensis) with Infected Ticks and Antibodies
- Hepatic iron Accumulation Is Not Directly Associated with Induction of DNA Strand Breaks in the Liver Cells of Long-Evans Cinnamon (LEC) Rats
- Inhibitory Effects of Trientine, a Copper-Chelating Agent, on Induction of DNA Strand Breaks in Kidney Cells of Long-Evans Cinnamon (LEC) Rats
- THE EFFECTS OF IONIZING RADIATION ON PROMOTER-DEPENDENT RNA SYNTHESIS
- Direct Detection by PCR of Escherichia coli O157 and Enteropathogens in Patients with Bloody Diarrhea
- THE INHIBITORY EFFECTS OF MgSO_4 ON THE MULTIPLICATION AND TRANSCRIPTION OF MOUSE HEPATITIS VIRUS
- Inhibition of Vero Cell Cytotoxic Activity in Escherichia coli O157 : H7 Lysates by Globotriaosylceramide, Gb3,from Bovine Milk
- Bioimaging Analysis of Cellular Uptake of Cholesterol-Conjugated Oligonucleotides Using a Real-Time Confocal Laser Microscope
- Comparison of OspA Serotypes for Borrelia burgdorferi Sensu Lato from Japan, Europe and North America
- Infectivity and Arthritis Induction of Borrelia japonica on SCID Mice and Immune Competent Mice: Possible Role of Galactosylceramide Binding Activity on Initiation of Infection
- Effect of Helicobacter pylori Lipopolysaccharides on Human Polymorphonuclear Neutrophils and Endothelial Cells
- Distribution and Effects of Styrene on Fetus in Pregnancy
- Augmentation of Interferon Production after Cell-Differentiation of U937 Cells by TPA
- T Cell Response to Borrelia garinii, Borrelia afzelii, and Borrelia japonica in Various Congenic Mouse Strains
- Effect of Antibiotics, Levofloxacin and Fosfomycin, on a Mouse Model with Escherichia coli O157 Infection
- Levels of Endogenous Interleukin-1, Interleukin-6, and Tumor Necrosis Factor in Congenic Mice Infected with Borrelia garinii
- Experimental Helicobacter pylori Infection in Association with Other Bacteria
- Role of Platelet-Activating-Factor(PAF)on Cellular Responses after Stimulation with Leptospire Lipopolysaccharide
- Bioimaging Analysis of Cellular Uptake and Intracellular Distribution of Oligonucleotide
- S期でX線照射されたLECラット細胞のG2/M期における異常な蓄積
- Trientine, a Copper-Chelating Agent, Induced Apoptosis in Murine Fibrosarcoma Cells by Activation of the p38 MAPK Pathway
- Production of Age-Related DNA Strand Breakage in Brain Cells of Senescence-Accelerated Prone (SAMP1) Mouse
- Kinetics of Radiation-Induced Nuclear Translocation of Ku-Proteins in Normal and Radiosensitive Rat Fibroblasts
- Radiation-Induced Nuclear Translocation of Ku Proteins in Rat Fibroblasts 2. Hyperradiosensitive LEG Rat Cells Defects Translocation of Ku Proteins after Irradiation
- Radiation-Induced Translocation of Ku proteins into Nuclei 1. Hypertonic Treatment Inhibit Both Translocation and Repair of PLD
- Radiation-hypersensitivity of the fibroblast from LEC strain rats - II
- Radiation-hypersensitivity of LEC strain rats
- Radiation-hypersensitivity of LEC strain rate controlled by a single autsomal recessive gene
- Protective Effect of Japanese Green Tea Extract on Gnotobiotic Mice Infeeted with an Escherichia coli Ol57: H7 Strain
- Adenocarcinoma Arising in a Tailgut Cyst : Report of a Case
- Management of gallbladder and common bile duct stones : Laparoscopic cholecystectomy combined with preoperative endoscopic sphincterotomy versus open surgery
- Radiofrequency Radiation at 40 kHz Induces Hepatic Injury in Long-Evans Cinnamon (LEC) Rats, an Animal Model for Human Wilson Disease
- Ability of Orally Administrated IFN-α4 to Inhibit Naturally Occurring Gingival Inflammation in Dogs
- Restriction Fragment Length Polymorphism in Helicobacter pylori Associated with Gastric Cancer and Duodenal Ulcer
- Platelet Responses after Stimulation with Lipopolysaccharide from Porphyromonas gingivalis
- Hepatocellular carcinoma complicated by gastrointestinal hemorrhage caused by direct tumor invasion of stomach
- Effect of UVA on RNA Synthesis in Isolated Chicken Liver Nuclei
- Microanalysis of Silicon in Chinese Hamster Spermatozoa
- EXPRESSION OF THE ENDOGENOUS MAREK'S DISEASE VIRUS ICP4 HOMOLOG (MDV ICP4) GENE IS ENHANCED IN LATENTLY INFECTED CELLS BY TRANSIENT TRANSFECTION WITH THE RECOMBINANT MDV ICP4 GENE
- RESTRICTION FRAGMENT LENGTH POLYMORPHISM FOR THE YC SUBUNIT GENE OF RAT LIVER GLUTATHIONE S-TRANSFERASE
- Levels of Porphyromonas gingivalis Fimbriae and Inflammatory Crytokines in Gingival Crevicular Fluid from Adult Human Subjects
- Structural Characterization of the O-Antigenic Polysaccharide Chain of Porphyromonas circumdentaria NCTC 12469
- Control of Immunologically Crossreactive Leptospiral Infection by Administration of Lipopolysaccharides from a Nonpathogenic Strain of Leptospira biflexa
- Effects of Long-Wave Ultraviolet (UVA) Radiation on MgCl_2-Dependent Structural Transition of Chromatin in Isolated Chicken Liver Nuclei
- THE EFFECT OF ULTRASOUND ON CALF THYMUS DNA AS A TEMPLATE FOR RNA SYNTHESIS
- Porphyromonas gingivals Fimbriae Induce Adhesion of Monocytic Cell Line U937 to Endothelial Cells
- Salt-Dependent Structural Changes of Chromatin in Isolated Chicken Liver Nuclei as Visualized by Scanning Electron Microscopy
- THE EFFECT OF IONIZING RADIATION ON CALF THYMUS DEOXYRIBONUCLEOPROTEIN AS A TEMPLATE FOR RNA SYNTHESIS
- Retroviral Sequence Located in Border Region of Short Unique Region and Short Terminal Repeat of Md5 Strain of Mareks Disease Virus Type 1
- Role of p38 Mapk in Development of Acute Hepatic Injury in Long-Evans Cinnamon (LEC) Rats, an Animal Model of Human Wilson's Disease
- Resistance to UV-Irradiation of DNA Synthesis in Fibroblast Cell Lines Derived from LEC Strain Rats.
- Higher Sensitivity in Induction of Apoptosis in Fibroblast Cell Lines Derived from LEC Strain Rats to UV-Irradiation.
- Effects of Antioxidants on Induction of Apoptosis in Bursal Cells of Fabricius during In Vitro Cultivation
- Wortmannin, a Radiation Sensitizer, Enhances the Radiosensitivity of WKAH Rat Cells but not That of LEC Rat Cells.