Ability of Orally Administrated IFN-α4 to Inhibit Naturally Occurring Gingival Inflammation in Dogs
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概要
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It has been reported that type I interferons (IFN-α/β) play an important role in innate immune responses against viral and bacterial infections. In this study, we used and examined naturally occurred canine periodontal disease to show the therapeutic efficacy of low dose oral administration (LDOA) of canine IFN-α subtype 4 (CaIFN-α4). We administrated purified recombinant CaIFN-α4 expressed in a baculovirus system to dogs with or without gingival inflammation. We found that LDOA of CaIFN-α4 reduce periodontopathic bactrerial counts. LDOA induced improvement of naturally occurring gingival inflammation, and reduction of the stress marker responses was also observed after LDOA. These results suggest that LDOA of CaIFN-α4 has effectiveness for improvement of naturally occurring gingival inflammation in dogs.
著者
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ISOGAI Emiko
Department of Hygiene, Health Sciences University of Hokkaido
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Ito Akira
Research Center For Interface Quantum Electronics And Graduate School Of Electronics And Information
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YOSHIOKA Kuniaki
Research Center for Biologicals, The Kitasato Institute
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SATO Ko
Research Center for Biologicals, The Kitasato Institute
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HIMENO Naomi
Research Center for Biologicals, The Kitasato Institute
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GOTANDA Toru
Research Center for Biologicals, The Kitasato Institute
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Isogai Emiko
Department of Preventive Dentistry, Health Sciences University of Hokkaido
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