Inhibitory Effects of Trientine, a Copper-Chelating Agent, on Induction of DNA Strand Breaks in Kidney Cells of Long-Evans Cinnamon (LEC) Rats
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概要
- 論文の詳細を見る
The effects of treatment with trientine, a specific copper-chelating agent, on the accumulation of copper and induction of DNA strand breaks were investigated in Long-Evans Cinnamon (LEC) rats, an animal model for human Wilsons disease. Copper accumulated in the kidneys of LEC rats in an age-dependent manner from 12 to 18 weeks of age. When LEC rats were treated with trientine from 10 weeks of age, renal copper contents did not increase and were maintained at the same levels as those in 4-week-old LEC rats. Estimation of the amounts of DNA single-strand breaks (SSBs) by comet assay showed that SSBs of DNA were induced in a substantial population of LEC rat renal cortex cells around 12 weeks of age and that the amounts of SSBs increased in an age-dependent manner from 12 to 18 weeks of age. When LEC rats were treated with trientine from 10 weeks of age, the observed number of cells with DNA damage decreased, suggesting that induction of SSBs of DNA was inhibited and/or SSBs were repaired during the period of treatment with trientine. The results show that SSBs of DNA in LEC rat kidney cells are induced prior to occurrence of clinical signs of hepatic injury and that treatment of LEC rats with trientine decreases the number of DNA strand breaks.
- 社団法人 日本実験動物学会の論文
- 2005-10-01
著者
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KON Yasuhiro
Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido Universi
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NAGAHATA Hajime
Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen Univeristy
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HIGUCHI Hidetoshi
Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen Univeristy
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Kon Yasuhiro
Laboratory Of Anatomy Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokka
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Kon Yasuhiro
Experimental Animal Science Graduate School Of Veterinary Medicine Hokkaido University
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Nakayama K
Hokkaido Institute Of Public Health
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HAYASHI Masanobu
Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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MIYANE Kazuhiro
Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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SENOU Misato
Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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ENDOH Daiji
Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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NAKAYAMA Kenji
Hokkaido Institute of Public Health
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OKUI Toyo
Hokkaido Institute of Public Health
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Senou Misato
Department Of Veterinary Radiology School Of Veterinary Medicine Rakuno Gakuen University
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Miyane Kazuhiro
Department Of Veterinary Radiology School Of Veterinary Medicine Rakuno Gakuen University
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Okui Toyo
酪農学園大学 獣医学部獣医放射線生物学
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Endoh Daiji
Faculty Of Veterinary Medicine Hokkaido Univ.
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Noda Hiroshi
Department Of Animal Health Faculty Of Veterinary Medicine Rakuno Gakuen University
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Nagahata H
Department Of Animal Health School Of Veterinary Medicine Rakuno Gakuen University
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Nagahata Hajime
Department Of Animal Health School Of Veterinary Medicine Rakuno Gakuen Univeristy
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Hayashi Masanobu
Department Of Experimental Radiobiology Faculty Of Veterinary Medicine Hokkaido University
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Higuchi H
Rakuno Gakuen Univ. Hokkaido
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Higuchi Hidetoshi
Department Of Animal Health School Of Veterinary Medicine Rakuno Gakuen Univeristy
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Hayashi Masanobu
Department Of Veterinary Radiology School Of Vterinary Medicine Rakuno Gakuen University
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ENDOH Daiji
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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HAYASHI Masanobu
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University
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