Effect of Collagen Oligopeptide Injection on Rabbit Tenositis(Anatomy)
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概要
- 論文の詳細を見る
Effects of the collagen oligopeptide (COP) were examined by its repeat injection into the inflammatory rabbit Achilles tendon (Tendo calcaneus communis), in which tenositis was induced by injection of bacterial collagenase. COP was evaluated 5 times over a period of 3 weeks to 1 month after injection of collagenase. At 1 month after treatment, the therapeutic effect of COP was evaluated by examining the structure of collagen fibrils, amount and components of glycosaminoglycans (GAGs) and matrix metalloproteinases (MMPs), and compared with the saline injection, control, and normal groups. The Achilles tendon of rabbit in the control group (no COP injection) and saline injection group showed a notable increase in the number of fine collagen fibrils, a change in GAG composition and increase in the amount of pro-MMP-2, indicating the weakening of the tendon. In contrast, the size distribution of collagen fibrils, GAG composition and the amount of pro-MMP-2 was similar to those in the normal group. These results suggest that COP injection promotes healing processes of the tendon injury.
- 社団法人日本獣医学会の論文
- 2008-12-25
著者
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Kokai Yasuo
Department Of Pathology Sapporo Medical University School Of Medicine
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Kokai Yasuo
酪農学園大学 獣医学部獣医解剖学
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Hosaka Yoshinao
Department of Veterinary Medicine, Tottori University
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Hosaka Yoshinao
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Hosaka Yoshinao
酪農学園大学 獣医学部獣医解剖学
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Hosaka Yoshinao
Department Of Biosciences School Of Veterinary Medicine Rakuno Gakuen University
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TAKEHANA Kazushige
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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WATANABE Takafumi
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Science
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Watanabe Takafumi
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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UEDA Hiromi
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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MINAGUCHI Jun
Department of Veterinary Anatomy, School of Veterinary Medicine
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MEGURI Natsuko
Department of Veterinary Anatomy, School of Veterinary Medicine
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Watanabe Tomomasa
Laboratory Of Experimental Animal Science Graduate School Of Veterinary Medicine Hokkaido University
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Takehana Kazushige
Department Of Veterinary Anatomy Faculty Of Dairy Science Rakuno Gakuen University
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Takehana Kazushige
Department Of Veterinary Anatomy Rakuno Gakuen University
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Ueda Hiromi
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Minaguchi Jun
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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NAGAYASU Aya
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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TANGKAWATTANA Prasarn
Department of Biomedical Engineering, School of Medicine, Sapporo Medical University
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Ueda Hiromi
Department Of Anatomy Nagoya City University Medical School
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Nagayasu Aya
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Minaguchi Jun
Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent
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Meguri Natsuko
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Watanabe T
Department Of Veterinary Anatomy School Of Veterinary Medicine Rakuno Gakuen University
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Watanabe Takafumi
Department Of Aerospace Engineering Osaka Prefecture University
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Tangkawattana Prasarn
Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Khon Kean University
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Kokai Yasuo
Department Of Biomedical Engineering School Of Medicine Sapporo Medical University
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Kokai Yasuo
Department Of Biomedical Engineering Cancer Research Institute Sapporo Medical University School Of
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Tangkawattana Prasarn
Department Of Biomedical Engineering School Of Medicine Sapporo Medical University
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Minaguchi Jun
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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Hosaka Yoshinao
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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Meguri Natsuko
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University
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