Effects of Quaternary Ammonium Compounds on the Degradation of Lipids in Lysosomes
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概要
- 論文の詳細を見る
We have examined effects of quaternary ammonium compounds on the in vitro degradation of endogenous lipids in isolated lysosomes. The degree of lipid degradation was assessed by determining hydrolysis products of labeled lipid. Lipolysis was inhibited by quaternary ammonium compounds. The degrees of inhibition were as follows : ethidium bromide>N-methylatropinium bromide (NMA)>tubocurarine. The inhibition of lipolysis by these quaternary ammonium compounds is not necessarily correlated with the differences in their polarties, molecular weight or structures. The degradation of three phospholipid classes was inhibited by NMA with phosphatidylcholine the most vulnerable. The effect of NMA on the hydrolysis of [^<14>C] dipalmitoylphosphatidylcholine (phospholipid) by lysosomal soluble proteins was also examined. The effect of NMA on phospholipase A_1 was assessed by the formation of lysophosphatidylcholine, and that on phospholipase C was assessed as the sum of mono-and diglyceride formations. The action of NMA on the phospholipid degradation was similar to that of cationic amphiphilic drugs, but it differed somewhat from that of chloroquine for each enzyme. From these results, it was concluded that one of the inhibitory mechanisms of phospholipid degradation by NMA was the direct interaction between NMA and phospholipase A_1 or C.
- 公益社団法人日本薬学会の論文
著者
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WATANABE Takafumi
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Science
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SUGA Tetsuya
Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Scien
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Watanabe T
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Suga T
Dept. Clin. Biochem. Sch. Pharm. Sci. Tokyo College Of Pharmacy
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Suga Tetsuya
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Suga Tetsuya
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Suga T
Department Of Clinical Biochemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Fujitani H
Azabu Univ. Sagamihara‐shi Jpn
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Fujitani H
Azabu Univ. Sagamihara Jpn
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MATSUMOTO Yoshio
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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FUJITANI Hideo
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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Watanabe Takafumi
Department Of Aerospace Engineering Osaka Prefecture University
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Matsumoto Y
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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