EFFECTS OF SOME HYPOLIPIDEMIC AGENTS ON BIOCHEMICAL VALUES AND HEPATIC PEROXISOMAL ENZYMES IN RATS : COMPARISON OF PROBUCOL, CGA, KCD-232,MLM-160,AL-369 AND CLINOFIBRATE WITH CLOFIBRATE
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概要
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The effect of some hypolipidemic agents, which are commercially available and those being developed. on certain biochemical values and on hepatic peroxisomal enzyme activities of rats were examined. Clofibrate (0.25% (w/w) in the diet), p-chlorophenoxyisobutyryl-glycinamide (CGA) (0.25%), clinofibrate (0.1%), KCD-232 (0.1%) and MLM-160 (0.1%) increased the activities of peroxisomal fatty acyl-CoA oxidizing system, carnitine acetyltransferase, and mitochondrial carnitine palmitoyltransferase. Of peroxisomal enzymes, catalase activity was increased by the above agents, whereas the activities of D-amino acid oxidase and urate oxidase were decreased by clofibrate and CGA, and but were increased by KCD-232 and MLM-160 which are structurally unrelated to clofibrate. No influence on these enzyme activities by AL-369 and probucol treatments were observed. Hepatomegaly was induced by clofibrate, CGA, KCD-232 and MLM-160. Concerning serum lipid levels, clofibrate, CGA, clinofibrate, KCD-232 and MLM-160 decreased both cholesterol and triglyceride levels, whereas probucol decreased only cholesterol level. AL-369 had no influence on serum lipid levels under this condition using normolipemic rat. From these results, it was concluded that differing clofibrate and CGA, clinofibrate, MLM-160 and KCD-232 might not induce peroxisome proliferation in hepatic cells, although these have an influence on the enzyme composition of hepatic peroxisomes.
- 公益社団法人日本薬学会の論文
著者
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HORIE Shuichi
Department of Clinical Biochemistry, Faculty of Pharmaceutical Sciences, Teikyo University
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WATANABE Takafumi
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Science
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SUGA Tetsuya
Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Scien
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Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Suga T
Dept. Clin. Biochem. Sch. Pharm. Sci. Tokyo College Of Pharmacy
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Suga Tetsuya
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Suga Tetsuya
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Suga T
Department Of Clinical Biochemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Horie Shuichi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy
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Horie Shuichi
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Teikyo University
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MITSUKAWA MIWAKO
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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SEKI KUNIO
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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Watanabe Takafumi
Department Of Aerospace Engineering Osaka Prefecture University
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Mitsukawa Miwako
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:department Of Development Morishita Ph
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Seki Kunio
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:department Of Development Morishita Ph
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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