Farnesol, a Morphogenetic Autoregulatory Substance in the Dimorphic Fungus Candida albicans, Inhibits Hyphae Growth through Suppression of a Mitogen-Activated Protein Kinase Cascade (Miscellaneous)
スポンサーリンク
概要
- 論文の詳細を見る
Candida albicans grew in hyphal form in RPMI1640, however, addition of farnesol inhibited the formation. Farnesol did not affect the expression of mRNAs related to cAMP-EFGl pathways. The mRNAs (HST7 and CPH1) in mitogen activated protein kinase (MAP) cascades were decreased in farnesol-treated cells, but CST20 was not. Furthermore, expression of general amino acid permease 1 (GAP1) was decreased by farnesol. We concluded that farnesol inhibits a MAP kinase cascades, and the suppression is a cause of interruption of hyphae formation.
- 公益社団法人日本薬学会の論文
- 2004-05-01
著者
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Sato Takashi
Dep. Of Biochemistry And Molecular Biology Tokyo Univ. Of Pharmacy And Life Sciences School Of Pharm
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Mikami Takeshi
Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo
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Mikami T
Department Of Microbiology Tohoku Pharmceutical University
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Mikami Takeshi
東北薬科大学 微生物学
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渡部 俊彦
東北薬大
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WATANABE TOSHIHIKO
Department of Surgery, Tachikawa Kyosai Hospital
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Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Mikami Takeshi
Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University
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SATO Tatsuki
Department of Microbiology, Tohoku Pharmaceutical University
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MATUMOTO Tatsuji
Department of Microbiology, Tohoku Pharmaceutical University
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MURAKAMI Tomonori
Department of Microbiology Tohoku College of Pharmacy
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Matsumoto T
Department Of Microbiology Tohoku Pharmceutical University
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Watanabe T
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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松本 達二
東北薬大
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Watanabe Toshihiko
Department Of Pediatric Surgery Saitama City Hospital
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Watanabe Toshihiko
Department Of Aeronautics And Astronautics University Of Tokyo
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松本 達二
Department of Microbiology, Tohoku Pharmaceutical University
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MIKAMI Takeshi
Department of Cardiovasology, Surugadai Nihon University Hospital
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