Bacillus cereus Dissociates Hemoglobin and Uses Released Heme as an Iron Source
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概要
- 論文の詳細を見る
B. cereus can use hemoglobin, heme, and heme-albumin complex as iron sources, but does not use other iron binding proteins such as transferrin and lactoferrin. B. cereus digests heme-protein complexes and elicits heme release from the proteins, but does not digest transferrin and lactoferrin. Dissociation of heme-proteins corresponded to the use of iron sources by B. cereus. This activity was completely inhibited by EDTA and phosphoramidon, and metalloendopeptidase inhibitors, therefore it appeared that the metalloprotease(s) are related to digestion and use of heme-protein complexes by B. cereus. B. cereus could bind released heme to its cells. These findings suggest that B. cereus can dissociate heme from heme-protein complex, and capture the released heme to use as an iron source.
- 公益社団法人日本薬学会の論文
- 1999-10-15
著者
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Mikami Takeshi
Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo
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Mikami T
Department Of Microbiology Tohoku Pharmceutical University
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Mikami Takeshi
東北薬科大学 微生物学
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Ikeda S
R&d Laboratories Nippon Organon K.k.
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Ikeda S
New Drug Discovery Research Laboratory Kanebo Ltd.
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Ikeda Shinobu
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Mikami Takeshi
Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University
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MATSUMOTO Tatsuji
Department of Microbiology, Tohoku Pharmacentical University
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SATO Noriyasu
Department of Microbiology, Tohoku College of Pharmacy
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MURAKAMI Tomonori
Department of Microbiology Tohoku College of Pharmacy
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Matsumoto T
Department Of Microbiology Tohoku Pharmceutical University
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IKEDA Seiichiro
Department of Microbiology, Tohoku Pharmaceutical University
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Sato N
R&d Laboratories En Otsuka Phamaceutical Co. Ltd.
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松本 達二
東北薬大
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松本 達二
Department of Microbiology, Tohoku Pharmaceutical University
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MIKAMI Takeshi
Department of Cardiovasology, Surugadai Nihon University Hospital
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