Effects of Antifungal Drugs on Proliferation Signals in Candida albicans(Microbiology)
スポンサーリンク
概要
- 論文の詳細を見る
The sensitivity of Candida albicans to antifungal drugs when cultured under aerobic and anaerobic conditions was measured. Ciclopirox olamine and siccanin were more effective under aerobic than under anaerobic conditions. Terbinafine, neticonazole and amphotericin B showed the same antifungal activity under both aerobic and anaerobic conditions. None of these antifungal activities were affected by the pH conditions. Terbinafine inhibited the elongation of hyphae, while neticonazole and amphotericin B induced proliferation of the yeast form. The expression of RAS1, EFG1 and CPH1 mRNAs was inhibited by these drugs. These results suggested that the inhibition of hyphal formation might be caused by disruption of the RAS1-signal pathway.
- 公益社団法人日本薬学会の論文
- 2006-05-01
著者
-
Mikami Takeshi
Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo
-
Mikami T
Department Of Microbiology Tohoku Pharmceutical University
-
Mikami Takeshi
東北薬科大学 微生物学
-
渡部 俊彦
東北薬大
-
Ogasawara Ayako
Department Of Microbiology Tohoku Pharmceutical University
-
WATANABE TOSHIHIKO
Department of Surgery, Tachikawa Kyosai Hospital
-
Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
-
Watanabe T
Dept. Clin. Biochem. Sch. Pharm. Sci. Tokyo College Of Pharmacy
-
Watanabe T
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
-
Mikami Takeshi
Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University
-
MATSUMOTO Tatsuji
Department of Microbiology, Tohoku Pharmacentical University
-
MATSUKI Mitsuo
Department of Microbiology, Tohoku Pharmaceutical University
-
KANATSU Hatsuki
Department of Microbiology, Tohoku Pharmaceutical University
-
MURAKAMI Tomonori
Department of Microbiology Tohoku College of Pharmacy
-
Matsumoto T
Department Of Microbiology Tohoku Pharmceutical University
-
Matsuki Mitsuo
Department Of Microbiology Tohoku Pharmaceutical University
-
Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
-
Watanabe T
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
-
Ogasawara Ayako
Department Of Microbiology Tohoku Pharmaceutical University
-
松本 達二
東北薬大
-
Kanatsu Hatsuki
Department Of Microbiology Tohoku Pharmaceutical University
-
Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
-
Watanabe Toshihiko
Department Of Aeronautics And Astronautics University Of Tokyo
-
Ogasawara Ayako
Department of Microbiology, Tohoku Pharmaceutical University
-
松本 達二
Department of Microbiology, Tohoku Pharmaceutical University
-
MIKAMI Takeshi
Department of Cardiovasology, Surugadai Nihon University Hospital
関連論文
- Effect of Propranolol on Hyphae Formation Signal in Candida albicans(Microbiology)
- 輸血用血液に混在する細菌検出方法の研究
- P-D-3 臨床分離 MRSA における ARBEKACIN 耐性機序の酵素学的検討
- Lipase-Catalyzed Hydrolysis of Some Racemic 1-Acetoxy-2-arylpropanes
- 酵母マンナン投与マウス肝クッパー細胞によるCandida Albicansの殺菌
- Photobacterium leiognathiルシフェラーゼ発現に及ぼすゲルコースの効果
- 血清型2マレック病ウイルス接種鶏における感染初期の病理発生〔英文〕
- CHARACTERIZATION OF TWO MONOCLONAL ANTIBODIES WHICH RECOGNIZE DIFFERENT SUBPOPULATIONS OF CHICKEN T LYMPHOCYTES
- BACTERIAL INFECTION WHICH PRODUCES HIGH MORTALITY IN CULTURED JAPANESE FLOUNDER (PARALICHTHYS OLIVACEUS) IN HOKKAIDO
- CHARACTERIZATION OF TRANSPLANTABLE SUBLINE MDCC-MSB1-CLO. 18 DERIVED FROM MDCC-MSB1
- PRELIMINARY SURVEY FOR ANTIBODIES AGAINST FIVE BOVINE VIRUSES IN CATTLE IN KOREA
- COMPARISON OF MEMBRANE IMMUNOFLUORESCENCE AND CYTOTOXICITY TESTS FOR DETECTION OF CELL SURFACE ANTIGENS OF MAREK'S DISEASE LYMPHOMA-DERIVED CELL LINE
- LACK OF HETEROTRANSPLANTATION OF MAREK'S DISEASE LYMPHOMA-DERIVED CELL LINES AND MD LYMPHOMA CELLS TO NUDE MICE
- Prevalence of Hepatitis E Virus (HEV) Infection in Wild Boars (Sus scrofa leucomystax) and Pigs in Gunma Prefecture, Japan(Public Health)
- Isolation and Phylogenetic Analysis of Arcobacter Spp. in Ground Chicken Meat and Environmental Water in Japan and Thailand
- Port Site Metastasis of Sigmoid Colon Cancer After a Laparoscopic Sigmoidectomy : Report of a Case
- The Enantioselective Metabolism of 4-Isopropenyltoluene in Rabbits
- The Enantioselective Metabolism of p-Cymene in Rabbits
- Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. I. Effects of Ginkgo biloba Leaf Extract on the Pharmacokinetics of Diltiazem in Rats(Biopharmacy)
- キチン・キトサンオリゴ糖による黒カビの増殖抑制効果
- 病原性真菌 Candida albicans の糖代謝に及ぼすグルコサミンの影響について
- 水溶性キチンの真菌ATP産生阻害効果の検討
- キチン・キトサン類の Cladoasporium cladosporioides に及ぼす効果
- キトサンオリゴ糖の Candida albicans 形態変化制御効果の検討
- Candida albicans 細胞壁成分による形態変化制御機構とキチナーゼとの関係
- キトサンオリゴ糖によるルシフェラーゼ発光現象の阻害
- Saccharomyces cerevisiae- and Candida albicans-Derived Mannan Induced Production of Tumor Necrosis Factor Alpha by Human Monocytes in a CD14- and Toll-Like Receptor 4-Dependent Manner
- First Isolation of Bartonella henselae Type I from a Cat-Scratch Disease Patient in Japan and Its Molecular Analysis
- マンナンによるCandida albicansのプラスチック製培養プレート接着阻害効果
- pH変化によるCandida albicans形態変化シグナルの解析
- Studies on Interactions between Functional Foods or Dietary Supplements and Medicines. IV. Effects of Ginkgo biloba Leaf Extract on the Pharmacokinetics and Pharmacodynamics of Nifedipine in Healthy Volunteers(Biopharmacy)
- INITIAL LESIONS IN CHICKENS INFECTED WITH JM STRAIN OF MAREK'S DISEASE VIRUS
- Carotid Rete Mirabile Associated With Subarachnoid Hemorrhage : Case Report
- Evaluation of Blood Flow in Carotid Artery Stenosis Using B-Flow Sonography
- グルタチオンのメラニン合成阻害機構
- システインのCladosporium cladosporioides増殖抑制効果
- アミノ酸を使用した黒カビ増殖阻害効果の検討
- 唾液成分ムチンによる Candida albicans 菌糸形成抑制効果
- 糖アルコールによる Candida albicans 二相性形態変化シグナルの解析
- N-アセチルノイラミン酸によるCandida albicans形態変化の制御について
- 菌密度変化に伴うCandida albicansの増殖時形態変化メカニズムの解析
- Candida albicans 培養上清によるC. albicans CGR1 転写阻害と酵母形への形態変化の促進
- Candida albicansとクリスタルバイオレットの結合機構の解析
- Production of Leukotrienes from Mouse Peritoneal Macrophages by Treatment with a Neutral Subfraction of Bakers' Yeast Mannan
- Toxicity Test of Nitrobenzene in Mice by Oral Administration (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- Toxicity Test of Dichloromethane and 1,2-and 1,3-Dichloropropanes (Regular Presentations) (Proceedings of the 9th Symposium on Environmental Pollutants and Toxicology)
- Application of Limulus Lysate Gelation Reaction to Environmental Pollution Analyses : Cross-Gelation Reaction with Several Simple Polysaccharides (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
- Acute Toxicity Testing of Some Chlorinated Lower Hydrocarbons, Dichloromethane, 1,2- and 1,3-Dichloropropanes (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
- Anti-Candida Activity of Sodium Sulfite(Microbiology)
- Antifungal Mechanism of Hinokitiol against Candida albicans(Microbiology)
- Chitohexose Induce the Yeast Proliferation of Candida albicans(Microbiology)
- Hyphal Formation of Candida albicans Is Inhibited by Salivary Mucin(Microbiology)
- Mechanism of Candida albicans Transformation in Response to Changes of pH(Microbiology)
- Effects of Antifungal Drugs on Proliferation Signals in Candida albicans(Microbiology)
- Change in the Respiration System of Candida albicans in the Lag and Log Growth Phase(Microbiology)
- Role of Ca^/Calmodulin Signaling Pathway on Morphological Development of Candida albicans(Miscellaneous)
- Farnesol, a Morphogenetic Autoregulatory Substance in the Dimorphic Fungus Candida albicans, Inhibits Hyphae Growth through Suppression of a Mitogen-Activated Protein Kinase Cascade (Miscellaneous)
- Use of Hemoglobin as an Iron Source by Bacillus cereus
- Anti Candida Activity of Induced Transferrin in Mice Immunized with Inactivated Candida albicans
- Anticandidal Activity of Polymorphonuclear Leukocytes and Serum Transferrin in Tumor-Implanted Mice
- Isolation and Characterization of a 66 - kDa Antigen from Culture Filtrate of Aspergillus fumigatus NCPF 2109
- IN VITRO CYTOLYSIS OF MM46 TUMOR CELLS BY MOUSE PHAGOCYTES ACTIVATED BY ACIDIC MANNAN FRACTION OF BAKERS' YEAST
- GROWTH-INHIBITION OF LEUKEMIA L-1210 ASCITES TUMOR BY COMBINATION OF CARRAGEENAN AND MITOMYCIN C IN VIVO
- 亜硫酸ナトリウムのCandida glabrata傷害作用
- Menadione処理したCandida albicans ROS産生機構の解析
- P-100 Two directional USG in the video assisted ano-rectoplasty (VAARP) and post operative anorectal function
- P-98 GROWTH DEVELOPMENT AFTER SUCCESSFUL LIVING DONOR LIVER TRANSPLANTATION IN CHILDREN
- Toxicity Test of Nitrobenzene and m-Dinitrobenzene in Mice by Oral Administration (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
- Identification of Inhibitory Component in Cinnamon : O-Methoxycinnamaldehyde Inhibits CYP1A2 and CYP2E1
- Hyphae Formation of Candida albicans Is Regulated by Polyamines(Miscellaneous)
- Bacillus cereus Dissociates Hemoglobin and Uses Released Heme as an Iron Source
- Lactoferrin Inhibits Bacillus cereus Growth and Heme Analogs Recover Its Growth
- Production of Interleukin-1 Activity of Kupffer Cells from Mice Treated with the Acidic Mannan Fraction of Bakers' Yeast
- Inhibition of the Activity of Mouse Macrophage Scavenger Receptors by Antioxidants
- Isolation of Feline Parvovirus from Peripheral Blood Mononuclear Cells of Cats in Northern Vietnam
- Replication of Feline Syncytial Virus in Feline T-Lymphoblastoid Cells and Induction of Apoptosis in the Cells
- Inhibition of Protein Phosphorylation in Macrophages by Antioxidants
- Water-soluble Antioxidants Inhibit Macrophage Recognition of Oxidized Erythrocytes
- ANTI-TUMOR IMMUNITY AGAINST MAREK'S DISEASE-DERIVED LYMPHOBLASTOID CELL LINE (MSB-1)
- Substrate Specificity and Some Other Enzymatic Properties of Dihydroceramide Desaturase(Ceramide Synthase)in Fetal Rat Skin^1
- Further Characterization of Equine Brain Gangliosides: The Presence of GM3 Having N-Glycolyl Neuraminic Acid in the Central Nervous System^1
- Chitooligosaccharides inhibit chemiluminescence of firefly luciferase
- Seroprevalence of Bartonella henselae, Toxoplasma gondii, FIV and FeLV Infections in Domestic Cats in Japan
- Growth-Inhibition by Hemin in K562 Human Leukemic Cells Is Related to Hemoglobin-Producing Activity
- Cloning and Expression of Bartonella henselae sucB Gene Encoding an Immunogenic Dihydrolipoamide Succinyltransferase Homologous Protein
- Serological Investigation of Bartonella henselae Infections in Clinically Cat-Scratch Disease-Suspected Patients, Patients with Cardiovascular Disease, and Healthy Veterinary Students in Japan
- PATHOLOGICAL STUDIES OF MAREK'S DISEASE IN JAPANESE QUAIL
- 糖質の標的指向性を応用した抗腫瘍性プロドラッグの開発について
- Menadione 処理した Candida albicans ROS 生産機構の解析
- 細胞壁マンナンの宿主細胞との反応性
- Candida albicans キチナーゼ産生機構の解析
- クリスタルバイオレットのキチン親和性と抗力ンジタ活性
- キチンによる Candida albicans 形態変化誘導活性
- 低分子キチンの Apo-transferrin 誘導効果
- キチンおよび低分子キチン長期経口投与老齢マウスの免疫細胞に及ぼす影響について
- キチン及びキトオリゴ糖長期経口投与のマウスに及ぼす影響について
- キチン質の感染症治療への応用
- キチン及び低分子キチン長期経口投与のマウスに及ぼす影響について(第2報)
- ポリガラクトサミン-アドリアマイシン複合体のマウス移植腫瘍に対する抗腫瘍性とその作用機作について
- Effect of Propranolol on Hyphae Formation Signal in Candida albicans