The Enantioselective Metabolism of 4-Isopropenyltoluene in Rabbits
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概要
- 論文の詳細を見る
4-Isopropenyltoluene (8) was administered orally to rabbits and the following four optically active metabolites, 2-(p-tolyl) propanoic acid (10), p-(1-carboxyethyl) benzoic acid (11), 2-hydroxy-2-(p-tolyl) propanoic acid (12), and 2-(p-tolyl)-1,2-propanediol (13) were isolated from urine in addition to an optically inactive metabolite, 4-isopropenylbenzoic acid (9). The enantiomeric ratios of the metabolites 10 and 11 were respectively R/S=33 : 67 and 39 : 61 (S predominance), whereas those of the metabolites 12 and 13 possessing a tertiary hydroxyl group were R/S=77 : 23 and 84 : 16 respectively (R predominance). The presumed metabolic pathways of 8 in rabbits leading to these metabolites are discussed.
- 社団法人日本薬学会の論文
- 1994-11-15
著者
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石田 孝
Hiroshima Institute Of Technology
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高石 喜久
徳島大院薬
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松本 高志
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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武田 美雄
徳島大学総合科学部生物環境資源化学分野
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武田 美雄
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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Mikami T
Department Of Microbiology Tohoku Pharmceutical University
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Mikami Takeshi
東北薬科大学 微生物学
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Takeda Y
Fac. Of Integrated Arts And Sciences Univ. Of Tokushima
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Takeda Y
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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八木 純平
Faculty of Integrated Arts and Sciences, The University of Tokushima
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Matsumoto T
Department Of Microbiology Tohoku Pharmceutical University
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八木 純平
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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松本 達二
東北薬大
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