Fungal Metabolites. X. The Effect of Peptide Antibiotics, Trichosporin-Bs, on the Respiratory Activity of Mitochondria
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概要
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The effect of the trichosporin-Bs, peptide antibiotics, on the respiration of mitochondria was investigated. Trichosporin-Bs stimulated the respiratory rate of state 4 rat liver mitochondria in a dose-dependent manner. The maximum respiratory rate obtained by trichosporin-Bs was essentially the same as for 2,4-dinitrophenol and SF6847. Trichosporin-B-VIb released oligomycin-inhibited respiration of mitochondria. This means that trichosporin-Bs are uncouplers of oxidative phosphorylation. The stimulatory effect of trichosporin-B-VIb, a component of trichosporin-Bs, on mitochondrial respiration was increased by inorganic phosphate but not by other permeant anions studied. These results suggest that the stimulation of mitochondrial respiration by trichosporin-B-VIb is mediated by the same mechanism as is operating in the case of hypelcins and alamethicins. Furthermore, the relative potencies of trichosporin-Bs on the mitochondrial respiration and their relative hydrophobicities were examined. A clear relationship was observed between the uncoupling potencies of trichosporin-Bs and their relative hydrophobicities.
- 社団法人日本薬学会の論文
- 1994-04-15
著者
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高石 喜久
徳島大院薬
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奥田 真弘
Faculty Of Pharmaceutical Sciences Kyoto University
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寺田 弘
Faculty of Pharmaceutical Sciences, University of Tokushima
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上里 新一
Faculty of Pharmaceutical Sciences, Kyoto University
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藤多 哲朗
Faculty of Pharmaceutical Sciences, The University of Tokushima
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高石 喜久
Faculty of Pharmaceutical Sciences, The University of Tokushima
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高石 喜久
Faculty Of Pharmaceutical Science Tokushima University
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藤多 哲朗
摂南大学薬学部
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藤多 哲朗
Faculty Of Pharmaceutical Sciences Kyoto University
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飯田 彰
京大 院 薬
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藤多 哲朗
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Takeda Y
Fac. Of Integrated Arts And Sciences Univ. Of Tokushima
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Takeda Y
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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上里 新一
京都大学薬学部
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Iida A
Graduate School Of Pharmaceutical Sciences Kyoto University
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Iida Akira
Faculty Of Pharmaceutical Sciences Kyoto University
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飯田 彰
Faculty of Pharmaceutical Sciences, Kyoto University
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長岡 康夫
Faculty of Pharmaceutical Sciences, Kyoto University
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上里 新一
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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寺田 弘
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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上里 新一
Faculty Of Pharmaceutical Sciences Kyoto University
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長岡 康夫
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Nagaoka Y
Faculty Of Pharmaceutical Sciences Kyoto University
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寺田 弘
Fac. Of Pharmaceutical Sciences Tokyo Univ. Of Sci.
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高石 喜久
Faculty of Integrated Arts and Sciences, University of Tokushima
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