Fungal Metabolites. XVII. Synthesis and NMR Study of Ion Channel-Forming Peptides, Trichosporin B-VIa and Its Derivative

スポンサーリンク

概要

• 論文の詳細を見る

• A membrane-modifying peptide antibiotic, trichosporin B-VIa, having catecholamine secretion-inducing activity on bovine adrenal chromaffin cells has been synthesized. Aib^<14>-Trichosporin B-VIa, in which Pro^<14> was replaced by Aib, has also been synthesized to modify the secondary structure of trichosporin B-VIa. Sequience-specific ^1H-NMR assignments of both peptides in methanol were achieved by using two-dimensional NMR techniques.

• 社団法人日本薬学会の論文
• 1994-06-15

著者

• 藤多 哲朗

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• 藤多 哲朗

  摂南大学薬学部

• 藤多 哲朗

  Faculty Of Pharmaceutical Sciences Kyoto University

• 飯田 彰

  京大 院 薬

• 藤多 哲朗

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Iida A

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Iida Akira

  Faculty Of Pharmaceutical Sciences Kyoto University

• 飯田 彰

  Faculty of Pharmaceutical Sciences, Kyoto University

• 長岡 康夫

  Faculty of Pharmaceutical Sciences, Kyoto University

• 長岡 康夫

  Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai

• Nagaoka Y

  Faculty Of Pharmaceutical Sciences Kyoto University

関連論文

• 85(P-87) DNAポリメラーゼβおよびDNAトポイソメラーゼII阻害物質を用いた両酵素の立体構造相関(ポスター発表の部)
• 127(P-70) トリコテシノール類の発がんプロモーター活性と合成研究(ポスター発表の部)
• On the Diterpenoids of Andrographis paniculata : X-Ray Crystallographic Analysis of Andrographolide and Structure Determination of New Minor Diterpenoids
• 酵母を用いた免疫抑制物質ISP-I耐性遺伝子のクローニング
• CTLL-2細胞におけるスフィンゴシン経路によるアポトーシス制御
• チョロギStachys sieboldi MIQ.の配糖体成分とそのヒアルロニダーゼ活性に及ぼす影響
• Antiproliferative Activity of Rhinacanthus nasutus (L.) KURZ Extracts and the Active Moiety, Rhinacanthin C(Pharmacology)
• INTERMEDIACY OF 10-HYDROXYGERANIOL, 10-HYDROXYNEROL AND IRIDODIAL IN THE BIOSYNTHESIS OF AJMALINE AND VOMILENINE IN RAUWOLFIA SERPENTINA SUSPENSION CULTURES
• 35 インド蛇木培養細胞から得られた鎖状モノテルペン1級アルコール脱水素酵素の反応(ポスター発表の部)
• Studies on the Constituents of Solanum Plants. V. The Constituents of S. lyratum THUNB. II
• Attempt to Detect Natural Anticancer Compounds-Protein Binding through Precursor Ion Scan and MS/MS Measurements
• Revision of the Structures of Isodonal, Rabdolasional and Related Diterpenoids
• Studies on the Diterpenoid Constituents of Rabdosia ternifolia : Structural Elucidation of New Diterpenoids, Rabdoternins A, B and C
• Rabdosia ternifolia(D.DON)HARAの成分 : 新ジテルペンIsodonoic Acidの構造
• 36 中国産Rabdosia属植物R.phyllostachys,R.rubescensならびにR.sculponeataの新ジテルペンの構造
• The Structure of Rubescensin C : A New Minor Diterpenoid isolated from Rabdosia rubescens
• 菊栽培農業者にみられるアレルギ-性接触性皮膚炎原因物質の探索 (厚生省補助研究「農業アレルギ-に関する研究」)
• 42 数種のモクセイ科植物のセコイリドイド配糖体の構造と生合成(口頭発表の部)
• トリコデルマ属菌から発見された新しい免疫抑制ペプチド
• Marrubinones A and B, New Labdane Diterpenoids from Marrubium astracanicum (Labiatae)
• Structures of Three New Diterpenoids, Fritillebic Acid and Fritillebins A and B, from Bulbs of Fritillaria ebeiensis G. D. Yu et G. Q. JI
• PROPERTIES OF TRICHOSPORIN-B-VIa-INDUCED CATECHOLAMINE SECRETION FROM BOVINE ADRENAL CHROMAFFIN CELLS
• Fungal Metabolites. XX. Effect of Proline Residue on the Structure of Ion-Channel-Forming Peptide, Trichosporin B-VIa
• Fungal Metabolites. XIX Structural Elucidation of Channel-Forming Peptides, Trichorovins-I-XIV, from the Fungus Trichoderma viride
• Structure Elucidation of Six Acylated Iridoid Glucosides from Jasminum hemsleyi
• EFFECT OF LIPOPHILICITY OF TRICHOSPORIN-Bs ON ION-CHANNEL FORMATION AND CATECHOLAMINE-RELEASING ACTIVITY
• Fungal Metabolities. XVIII. New Membrane-Modifying Peptides, Trichorozins I-IV, from the Fungus Trichoderma harzianum
• P-43 木材腐朽菌Trichoderma polysporumの生産する抗真菌活性ペプチド、trichopolyn類の構造(ポスター発表の部)
• Fungal Metabolites. XVII. Synthesis and NMR Study of Ion Channel-Forming Peptides, Trichosporin B-VIa and Its Derivative
• Fungal Metabolites. XVI. Structures of New Peptaibols, Trichokindins I-VII, from the Fungus Trichoderma harzianum
• Fungal Metabolites. XV. Primary Structures of Antibiotic Peptides, Hypelcins B-I, B-II, B-III, B-IV and B-V, from Hypocrea peltata. Application of Electrospray Mass Spectrometry and Electrospray Mass Spectrometry/Mass Spectrometry
• Fungal Metabolites. X. The Effect of Peptide Antibiotics, Trichosporin-Bs, on the Respiratory Activity of Mitochondria
• Fungal Metabolites. XIII. Isolation and Structural Elucidation of New Peptaibols, Trichodecenins-I and -II, from Trichoderma viride
• Fungal Metabolites. IX. Synthesis of a Membrane-Modifying Peptide, Hypelcin A-III, from Hypocrea peltata
• 32 Trichoderma virideの生産するカテコールアミン放出活性ペプチド、Trichocellin類の構造(口頭発表の部)
• 87 不完全菌類Trichoderma属菌の生産する新規peptaibol(口頭発表の部)
• Thermospray Liquid Chromatographic/Mass Spectrometric Analysis of Iridoid Glycosides from Gardenia jasminoides
• Fungal Metabolites. IV. : Synthesis of an Antibiotic Peptide, Trichosporin B-V, from Trichoderma polysporum
• 免疫抑制剤の話
• 冬虫夏草菌類から免疫抑制物質 : 創薬を目指して
• 122(P68) 免疫抑制活性物質ISP-I (Myriocin)の活性発現に必要な最小基礎構造(2-Aminoalcohol)の探索(ポスター発表の部)
• 14 新規免疫抑制活性物質mycestericin類D,E,FおよびGの絶対配置の決定と全合成(口頭発表の部)
• Inorganic Chemical Approaches to Pharmacognosy. VII. : X-Ray Fluorescence Spectrometric Studies on the Inorganic Constituents of Crude Drugs. (5). The Relationship between Inorganic Constituents of Plants and the Soils on Which They Are Grown
• Diterpenoid Constituents of Rabdosia umbrosa (MAXIM.) : Isolation and Structure Elucidation of Two New Diterpenoids, Umbrosianin and Rabdoumbrosanin
• シイタケを病気にするキノコの話 : オオボタンタケの活性成分
• 5 TRICHOSPORIN類の単離と構造決定(ポスター発表の部)
• An Intramolecular Hydride Shift in Derivatives of Kamebakaurin and kamebacetal A
• 20 Trichoderma polysporum代謝産物Trichosporin類の単離と構造
• (119) トリコデルマ菌の侵入によって誘起されるシイタケ菌糸の抗菌性物質生産量の増大 (昭和61年度日本植物病理学会大会講演要旨)
• Fungal Metabolites. II. Structural Elucidation of Minor Metabolites, Valinotricin, Cyclonerodiol Oxide, and Epicyclonerodiol Oxide, from Trichoderma polysporum
• FURTHER INVESTIGATION OF PEPTIDE ANTIBIOTIC, HYPELCIN A : ISOLATION AND STRUCTURES OF HYPELCINS A-I, A-II, A-III, AND A-IV
• (128) シイタケと Trichoderma spp. の拮抗 : 9. トリコポリンのシイタケに対する影響 (昭和59年度 日本植物病理学会大会講演要旨)
• Fungal Metabolites. I. Isolation and Biological Activities of Hypelcins A and B (Growth Inhibitors against Lentinus edodes) from Hypocrea peltata
• 天然有機化合物構造決定への応用--α-アミノイソ酪酸含有ペプチド性抗生物質
• 56 シイタケ菌発育阻害因子,Trichopolynの構造研究
• 14 イオノフォア様作用を有する木材腐朽菌生産ペプチドの構造
• Revised Structures of Inflexin and Related Diterpenoids
• 分子標的制癌剤の開発研究 (産学連携への掛け橋)
• Studies on the Bacterial Gall of Myrica rubra : Isolation of a New [7,0]-Metacyclophan from the Gall and DL-β-Phenyllactic Acid from the Culture of Gall-Forming Bacteria(Pharmacognosy,Chemical)
• 27 新規発ガンプロモーター、trichothecinol A(口頭発表の部)
• 49 Trichoderma harzianumの生産する新規抗生ペプタイドの構造(口頭発表の部)
• 24 ATPaseドメインを標的とするDNAトポイソメラーゼII阻害剤(口頭発表の部)
• Effects of Various Storage Conditions and Alterations of Antioxidant Contents on Chromatic Aberration of Hydroquinone Ointment(Biopharmacy)
• 4 カメバヒキオコシの新ジテルペン,Leukamenin類の構造
• 105(P-58) ヌクレオシド系酵素阻害剤の作用機序に基づく設計と合成(ポスター発表の部)
• 57 セキヤノアキチョウジの抗菌性新ジテルペン,effusanin類の構造
• Pharmaceutical and Clinical Assessment of Hydroquinone Ointment Prepared by Extemporaneous Nonsterile Compounding
• Peptaibolとその誘導体のイオンチャネル特性
• アルケニルホスホナートを基盤とする炭素-炭素結合形成反応の開発
• 良薬口に苦し延命草,味は甘なり冬虫夏草(日本生薬学会設立50周年記念)
• 免疫抑制剤の話(免疫と化学)

もっと見る 閉じる

スポンサーリンク