87 不完全菌類Trichoderma属菌の生産する新規peptaibol(口頭発表の部)

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Trichoderma spp. are active as mycoparasites. Therefore, they can serve as potential biocontrol agents. Various antibiotic peptides, peptaibols, have been isolated from Trichoderma spp. Their structures are characterized as follows; 1) both N-terminal and C-terminal amino acids are protected, 2) a high proportion of abnormal amino acids, α-aminoisobutyric acid (Aib) and isovaline (Iva) are incorporated, and 3) a labile Aib-Pro peptide bond is present. New peptaibols, trichorozin (TZ)-I〜IV from T. harzianum, trichodecenin (TD)-I and -II, and trichorovins (TVs) from T. viride have been isolated from their conidia, respectively. The primary structures of the former two peptide groups were clearly established by FABMS, FABMS/MS and NMR. TZ-I〜IV are composed of eleven amino acid residues. The N-terminals are all protected by an acetyl group and the C-terminal amino acids are linked with a valinol (TZ-I, -II) or a leucinol (TZ-III, -IV). On the other hand, TD-I and -II are composed of seven amino acid residues. The N-terminals are protected by a cis-4-decenoyl group and the C-terminal amino acids are linked with a leucinol. In addition, TD-I and -II contain no Aib-Pro peptide bond. Thus, TD-I and -II were found to belong to a new type of peptaibols. TZ-I〜IV and TD-II were synthesized to confirm their structures. TVs having the molecular weights ca. 1200 showed similar FABMS spectra to those of TZs. However, TVs were hardly separatable. Thus, we tried to determine their amino acid sequences by FABMS/MS in the state of a mixture.
天然有機化合物討論会の論文
1991-09-07

87 不完全菌類Trichoderma属菌の生産する新規peptaibol(口頭発表の部)

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