49 Trichoderma harzianumの生産する新規抗生ペプタイドの構造(口頭発表の部)

概要

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Trichoderma spp. are active as mycoparasites and, therefore, can serve as potential biocontrol agents. We found in dual culture studies on agar medium that Trichoderma harzianum killed most wood decay fungi examined. New antibiotic peptides, trichokindin (TK)-I〜X, which belong to a class of peptaibols like alamethicin and suzukacillin, were isolated from the spores of T. harzianum. The primary structure of TK-X(10) was clearly established by FABMS and FABMS/MS. The N-terminal of (10) is protected by an acetyl group and the C-terminal is linked with an isoleucinol (Iol). The peptide contains a high proportion of abnormal amino acids, α-aminoisobutyric acid (Aib) and isovaline (Iva). The peptides, trichokindin-IV〜IX (4〜9), have all about 1800 of molecular weight and have a similar structure, in which an aminoalcohol is Iol or leicinol (Lol), to TK-X. The other peptides, trichokindin-I〜III (1〜3), whose molecular weights are about 1200, are also protected by an acetyl group. Their total structure are not yet elucidated.
1989-09-17