生薬および関連植物の抗コクシジウム活性成分の探索(I) : アジサイからのcisならびにtrans-febrifugineの単離および抗コクシジウム活性について

概要

論文の詳細を見る
Twentythree crude drugs and related plants were examined for their anticoccidial activity by the use of the experimental coccidiosis in chicken. The activity was found in the dry leaves and calyxes of some Hydrangea plants. As the active components of H. macrophylla subsp. macrophylla forma macrophylla, febrifugines were isolated which have been known to be contained in Dichroa febrifuga and H. umbellata. However, although the febrifugines in the latter two plants were reported to be mainly trans, in the H. macrophylla plants, cis-febrifugine was found to be a major component and the trans-counterpart, a minor component. Furthermore, the cis-isomer showed no anticoccidial activity in chicken even at the concentration level of 25 times the effective dose (3 ppm, IE=100) of the trans-isomer.
日本生薬学会の論文
1990-12-20