連続ストレス負荷マウスの性行動及び学習行動に対するイリドイドの影響
スポンサーリンク
概要
- 論文の詳細を見る
Effects of iridoid glycosides on sex- and learning-behaviours induced by chronic"hanging stress"in mice, were studied. Drugs at a dose of 50 mg/kg were given orally every day after the exposure to stress. Geniposide and geniposidic acid showed a protective effect against decrease in sex behaviours, acceleration of extinction of memory, increase in failure of retrieval of memory, decrease of rectal temperature and enlargement of adrenal gland induced by the exposure to stress. Genipin showed a protective effect against decrease in licking, acceleration of extinction of memory, increase in failure of retrieval of memory and enlargement of adrenal gland, but promoted decrease in rectal temperature. Monotropein and gardenoside showed a weak protective effect against decrease in sex behaviours and acceleration of extinction of memory. Catalpol, aucubin and mussaenoside showed a weak protective effect against acceleration of extinction of memory, and mussaenoside showed an additional protective effect against increase in failure of retrieval of memory and decrease in rectal temperature.
- 社団法人日本薬学会の論文
- 1988-06-25
著者
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斎藤 洋
東京大学 薬 薬品作用
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斎藤 洋
東京大学薬学部
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井上 博之
京都大学薬学部
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西山 信好
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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貴志 豊和
武田薬品工業(株)中央研究所東京支所
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今井 孝司
武田薬品工業(株)中央研究所
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西山 信好
東京大学薬学部
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西山 信好
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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貴志 豊和
武田薬品工業(株)中央研究所
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今井 孝司
武田薬品工業
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Nishiyama Nobuyoshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University
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