Arylamine N-Glucuronide and its Structure.
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概要
- 論文の詳細を見る
In connection with the known fact that some aromatic amines are metabolized and excreted in urine as glucuronic acid conjugates, the N-glucosyluronates of primary aromatic amines, such as aniline, toluidine, p-chloroaniline, p-aminoazobenzene, p-dimethyl-aminoaniline, and p-phenylenediamine, were prepared. The same compound of secondary amines were not obtained. It was established that the conjugate should have a structure of N-glucopyranosyluronic acid, possibly in β-configuration, from the fact the acetylation product derived from methyl ester of glucuronic acid conjugate of aniline was identical with the compound prepared from methyl (2,3,4-tri-O-acetylglucopyranosyl-bromid) uronate and aniline.
- 公益社団法人日本薬学会の論文
- 1959-05-10
著者
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滝谷 昭司
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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石舘 守三
Faculty of Pharmaceutical Sciences, University of Tokyo
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石舘 守三
Faculty Of Pharmaceutical Sciences Hokkaido University
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貴志 豊和
Central Research Division Takeda Chemical Industries Ltd.
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貴志 豊和
武田薬品工業(株)中央研究所
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貴志 豊和
Iatrochemical Institute Of Pharmacological Research Foundation
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