The Metabolism of p-Dimethylaminoazobenzene and Related Compounds. I. Metabolites of p-Dimethylaminoazobenzene in Dog Urine.

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概要

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• The urinary metabolites of p-dimethylaminoazobenzene (DAB) in dog were studied, and in this connection, the metabolites of p-aminoazobenzene (AB) and 4'-hydroxy-4-aminoazobenzene (4'-OH-AB) were also examined. From the hydrolyzed 24-hr. urine after administration of DAB, o-aminophenol, p-aminophenol, aniline, p-phenylenediamine, AB, and p-methylaminoazobenzene (MAB) were detected. The amount of o-aminophenol was larger than that of the other amines. By paper chromatography 5-phenylazo-2-aminophenyl hydrogen sulfate (3-HSO_3O-AB), 3-HSO_3O-MAB, and 4'-HSO_3O-AB were respectively identified from the 3- to 7-hr. DAB-urine. The presence of 3-HSO_3O-AB N-glucosiduronic acid in the DAB- and AB-urine was assumed from their paper chromatographic behavior.

• 公益社団法人日本薬学会の論文
• 1959-02-10

著者

• 橋本 嘉幸

  Pharmaceutical Institute Tohoku University

• 橋本 嘉幸

  Faculty of Pharmaceutical Sciences, Tohoku University

• 石舘 守三

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 石舘 守三

  Faculty Of Pharmaceutical Sciences Hokkaido University

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