Studies on N-Hydroxy-4-aminoazo Dyes. I. Synthesis of N-Hydroxy-N-methyl-4-aminoazo Dyes and the Acyl Derivatives, and Their Degradation in Alkaline Solution
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概要
- 論文の詳細を見る
Alkaline hydrolysis of N-benzoyloxy-N-methyl-4-aminoazobenzene (II) in the presence of ascorbic acid gave N-hydroxy-N-methyl-4-aminoazobenzene (I) which has been estimated as proximate compound of hepatocarcinogenic N-methyl-or N, N-dimethyl-4-aminoazobenzene. Several acyl derivatives of I including acetyl derivative were synthesized. Alkaline treatment of I or II in the presence of dissolved oxygen, yield 4-nitroazobenzene (IV) and 4,4′-bisphenylazo-azoxybenzene (V), probably through intermediate forms, nitron and hydroxylamine compound.
- 公益社団法人日本薬学会の論文
- 1976-07-25
著者
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出川 雅邦
東北大学 薬学部 衛生化学教室
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橋本 嘉幸
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University:(present Addre
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出川 雅邦
東北大学薬学部
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出川 雅邦
Faculty of Pharmaceutical Sciences, Tohoku University
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橋本 嘉幸
Faculty of Pharmaceutical Sciences, Tohoku University
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