Immunoselective Cell Growth Inhibition by Antibody-Adriamycin Conjugates Targeting c-erbB-2 Product on Human Cancer Cells
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概要
- 論文の詳細を見る
Monoclonal antibodies targeting c-erbB-2 protooncogene product p185 were conjugated with adriamycin via a pH-sensitive spacer. The resultant antibody-adriamycin conjugates showed immunoselective binding, internalization and cytotoxicity to p185-positive human breast cancer cell SKBr-3 and gastric cancer cell MKN-7,but not to normal human lymphocytes.
- 社団法人日本薬学会の論文
- 1995-09-15
著者
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鈴木 真也
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University
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橋本 嘉幸
佐々木研
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橋本 嘉幸
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University:(present Addre
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益子 高
東北大・薬・遺伝子薬学
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Masuko Takashi
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Suzuki S
Faculty Of Pharmacy Meiji University
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田中 恵
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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益子 高
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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田中 恵
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University
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